Fenleuton

Fenleuton

SCHEMBL74861

CC(C#Cc1cccc(Oc2ccc(F)cc2)c1)N(O)C(N)=O

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALOX5 P09917 18/20 1.00
EPHX2 P34913 10/20 0.57
MAPT P10636 2/20 0.57
MEN1 O00255 1/20 0.57
ALDH1A1 P00352 1/20 0.57
TP53 P04637 1/20 0.57
CYP1A2 P05177 1/20 0.57
CYP3A4 P08684 1/20 0.57
CYP2D6 P10635 1/20 0.57
CYP2C9 P11712 1/20 0.57
HPGD P15428 1/20 0.57
ALOX15 P16050 1/20 0.57
TSHR P16473 1/20 0.57
ALOX12 P18054 1/20 0.57
NFKB1 P19838 1/20 0.57
MAPK1 P28482 1/20 0.57
CYP2C19 P33261 1/20 0.57
KMT2A Q03164 1/20 0.57
HIF1A Q16665 1/20 0.57
LMNA P02545 1/20 0.57

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Fenleuton SCHEMBL31539081 1.00 ALOX5 (1.00) ALOX5EPHX2MAPTMEN1ALDH1A1
SCHEMBL13140097 0.91 ALOX5 (0.83) ALOX5EPHX2MAPTMEN1ALDH1A1
SCHEMBL9046388 0.91 ALOX5 (1.00) ALOX5EPHX2ACACBACACA
SCHEMBL9048463 0.90 ALOX5 (0.84) ALOX5EPHX2MAPTMEN1ALDH1A1
SCHEMBL9047251 0.90 ALOX5 (0.84) ALOX5EPHX2MAPTMEN1ALDH1A1
SCHEMBL9046519 0.89 ALOX5 (0.83) ALOX5EPHX2ACACBACACA
SCHEMBL9047878 0.88 ALOX5 (0.78) ALOX5EPHX2MAPTMEN1ALDH1A1
SCHEMBL9047572 0.88 ALOX5 (0.78) ALOX5EPHX2MAPTMEN1ALDH1A1
SCHEMBL9049055 0.87 ALOX5 (0.79) ALOX5EPHX2MAPTMEN1ALDH1A1
SCHEMBL9047950 0.86 ALOX5 (0.83) ALOX5EPHX2MAPTMEN1ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1816 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250017878-A1 USE OF NADOLOL TO TREAT CHRONIC OBSTRUCTIVE PULMONARY DISEASE BY BLOCKAGE OF THE ARRESTIN-2 PATHWAY CHRONIC AIRWAY THERAPEUTICS LTD (AU) 2025-01-16 US claimed
WO-2024189434-A1 USE OF NADOLOL TO TREAT PULMONARY SYMPTOMS ASSOCIATED WITH INFECTIONS WITH SARS-CoV-2 CHRONIC AIRWAY THERAPEUTICS LIMITED (AU) 2024-09-19 WO claimed
EP-4304717-A1 USE OF NADOLOL TO TREAT CHRONIC OBSTRUCTIVE PULMONARY DISEASE BY BLOCKAGE OF THE ARRESTIN-2 PATHWAY Chronic Airway Therapeutics Limited (AU) 2024-01-17 EP claimed
WO-2022192252-A1 USE OF NADOLOL TO TREAT CHRONIC OBSTRUCTIVE PULMONARY DISEASE BY BLOCKAGE OF THE ARRESTIN-2 PATHWAY CHRONIC AIRWAY THERAPEUTICS LIMITED (AU) 2022-09-15 WO claimed
EP-3345897-A1 AMORPHOUS (5-FLUORO-2-METHYL-3-QUINOLIN-2-YLMETHYL-INDOL-1-YL)-ACETIC ACID Atopix Therapeutics Limited (GB) 2018-07-11 EP claimed
US-10011584-B2 Polymorphic form of [5-fluoro-3-({2-[(4-fluorobenzene) sulfonyl]pyridin-3-yl}methyl)-2-methylindol-1-yl]-acetic acid ATOPIX THERAPEUTICS LIMITED (GB) 2018-07-03 US claimed
US-9951042-B2 Polymorphic form of [5-fluoro-3-({2-[(4-fluorobenzene) sulfonyl] pyridin-3-yl}methyl)-2-methylindol-1-yl]-acetic acid ATOPIX THERAPEUTICS LIMITED (GB) 2018-04-24 US claimed
EP-2697215-B1 AMORPHOUS (5-FLUORO-2-METHYL-3-QUINOLIN-2-YLMETHYL-INDOL-1-YL)-ACETIC ACID ATOPIX THERAPEUTICS LTD (GB) 2017-11-22 EP claimed
US-20170121306-A1 POLYMORPHIC FORM OF [5-FLUORO-3-(METHYL)-2-METHYLINDOL-1-YL]-ACETIC ACID SOLVIAS AG (CH) 2017-05-04 US claimed
EP-3137452-A1 POLYMORPHIC FORM OF [5-FLUORO-3-({2-[(4-FLUOROBENZENE) SULFONYL]PYRIDIN-3-YL}METHYL)-2-METHYLINDOL-1-YL]-ACETIC ACID Atopix Therapeutics Limited (GB) 2017-03-08 EP claimed
WO-2001057036-A1 NICOTINAMIDE BENZOFUSED-HETEROCYCLYL DERIVATIVES USEFUL AS SELECTIVE INHIBITORS OF PDE4 ISOZYMES PFIZER PRODUCTS INC. (US) 2001-08-09 WO claimed
EP-0850217-B1 PROCESS FOR THE PREPARATION OF ARYLALKYNYL-N-HYDROXYUREA DERIVATIVES HAVING LIPOXYGENASE INHIBITORY ACTIVITY ABBOTT LAB (US) 2000-04-05 EP claimed
EP-0850217-A1 PROCESS FOR THE PREPARATION OF ARYLALKYNYL-N-HYDROXYUREA DERIVATIVES HAVING LIPOXYGENASE INHIBITORY ACTIVITY Abbott Laboratories (US) 1998-07-01 EP claimed
US-5714633-A Process for the preparation of arylalkynyl-N-hydroxyurea derivatives having lipoxygenase inhibitory activity ABBOTT LABORATORIES (US) 1998-02-03 US claimed
WO-1997010206-A1 PROCESS FOR THE PREPARATION OF ARYLALKYNYL-N-HYDROXYUREA DERIVATIVES HAVING LIPOXYGENASE INHIBITORY ACTIVITY ABBOTT LABORATORIES (US) 1997-03-20 WO claimed
EP-0540673-B1 ACETYLENE DERIVATIVES HAVING LIPOXYGENASE INHIBITORY ACTIVITY ABBOTT LAB (US) 1996-10-16 EP claimed
US-5476873-A Inhibit biosynthesis of leukotrienes ABBOTT LABORATORIES (US) 1995-12-19 US claimed
EP-0540673-A4 1994-04-27 EP claimed
EP-0540673-A1 ACETYLENE DERIVATIVES HAVING LIPOXYGENASE INHIBITORY ACTIVITY. ABBOTT LAB (US) 1993-05-12 EP claimed
WO-1992001682-A1 ACETYLENE DERIVATIVES HAVING LIPOXYGENASE INHIBITORY ACTIVITY ABBOTT LABORATORIES (US) 1992-02-06 WO claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10011584-B2 Polymorphic form of [5-fluoro-3-({2-[(4-fluorobenzene) sulfonyl]pyridin-3-yl}methyl)-2-methylindol-1-yl]-acetic acid CYP1B1, CYP3A5, CYP1A1 ALOX5 254/4885EPHX2 1284/4885MAPT 1298/4885
US-20250017878-A1 USE OF NADOLOL TO TREAT CHRONIC OBSTRUCTIVE PULMONARY DISEASE BY BLOCKAGE OF THE ARRESTIN-2 PATHWAY ARRB1, ADRB2, ADRB1 ALOX5 2744/4885EPHX2 972/4885MAPT 1043/4885
US-20170121306-A1 POLYMORPHIC FORM OF [5-FLUORO-3-(METHYL)-2-METHYLINDOL-1-YL]-ACETIC ACID UGT1A1, CYP3A5, CYP2D6 ALOX5 275/4885EPHX2 772/4885MAPT 1222/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.