Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIK1 | P39086 | 3/20 | 0.34 |
| ▸ | GRIK2 | Q13002 | 3/20 | 0.34 |
| ▸ | DPP4 | P27487 | 1/20 | 0.33 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.33 |
| ▸ | BLM | P54132 | 1/20 | 0.33 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.31 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8515622 | 0.85 | DPP4 (0.33) | GRIK1GRIK2DPP4ALDH1A1 | |
| SCHEMBL30015378 | 0.79 | DPP4 (0.38) | GRIK1GRIK2DPP4SLC6A2SLC6A4 | |
| SCHEMBL251436 | 0.76 | DPP4 (0.36) | GRIK1GRIK2DPP4 | |
| SCHEMBL8436428 | 0.76 | GABRR1 (0.33) | GRIK1GRIK2SLC6A2SLC6A4BLM | |
| SCHEMBL2425777 | 0.75 | GRIK1 (0.33) | GRIK1GRIK2DPP4 | |
| SCHEMBL170266 | 0.71 | — | — | |
| SCHEMBL31676717 | 0.71 | SLC22A6 (0.39) | GRIK1GRIK2DPP4GRM1GRM2 | |
| Aspartic Acid SCHEMBL28676864 | 0.70 | GRIK1 (0.50) | GRIK1GRIK2GRM1GRM2 | |
| SCHEMBL31196357 | 0.68 | GRIK1 (0.38) | GRIK1GRIK2SLC6A2SLC6A4BLM | |
| SCHEMBL28876474 | 0.68 | ALDH1A1 (0.34) | DPP4MEN1TSHRKMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5922319-A | REDUCING SCARING IN EYES | UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION (US) | 1999-07-13 | — | — | US | disclosed |
| US-5162307-A | Treatment of emphysema | BOARD OF TRUSTEES OF THE UNIVERSITY OF KENTUCKY (US) | 1992-11-10 | — | — | US | disclosed |
| EP-0403605-A4 | ELASTASE INHIBITING POLYMERS AND METHODS | UNIV KENTUCKY RES FOUND (US) | 1991-08-21 | — | — | EP | disclosed |
| EP-0396709-A4 | HUMAN LEUKOCYTE ELASTASE INHIBITORS AND METHODS OF PRODUCING AND USING SAME | — | 1991-05-22 | — | — | EP | disclosed |
| EP-0403605-A1 | ELASTASE INHIBITING POLYMERS AND METHODS | UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION (US) | 1990-12-27 | — | — | EP | disclosed |
| EP-0396709-A1 | HUMAN LEUKOCYTE ELASTASE INHIBITORS AND METHODS OF PRODUCING AND USING SAME | UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION (US) | 1990-11-14 | — | — | EP | disclosed |
| EP-0368449-A2 | Elastase inhibiting polymers and methods to produce them | Digenis, George Alexander (US) | 1990-05-16 | — | — | EP | disclosed |
| EP-0367514-A2 | Human leukocyte elastase inhibitors and methods for producing and using same | UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION (US) | 1990-05-09 | — | — | EP | disclosed |
| WO-1990004409-A1 | HUMAN LEUKOCYTE ELASTASE INHIBITORS AND METHODS OF PRODUCING AND USING SAME | UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION (US) | 1990-05-03 | — | — | WO | disclosed |
| WO-1990002558-A1 | ELASTASE INHIBITING POLYMERS AND METHODS | UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION (US) | 1990-03-22 | — | — | WO | disclosed |