Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 3/20 | 0.43 |
| ▸ | CTSK | P43235 | 3/20 | 0.42 |
| ▸ | KDM5C | P41229 | 3/20 | 0.41 |
| ▸ | KDM4C | Q9H3R0 | 3/20 | 0.41 |
| ▸ | KDM2A | Q9Y2K7 | 3/20 | 0.41 |
| ▸ | KDM3A | Q9Y4C1 | 3/20 | 0.41 |
| ▸ | KDM6B | O15054 | 2/20 | 0.41 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.40 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | ECE2 | P0DPD6 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | HTR1A | P08908 | 1/20 | 0.38 |
| ▸ | HTR7 | P34969 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | CTSL | P07711 | 2/20 | 0.38 |
| ▸ | CTSB | P07858 | 2/20 | 0.38 |
| ▸ | CTSS | P25774 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5105817 | 0.82 | CTSK (0.49) | POLBCTSKKDM5CKDM4CKDM2A | |
| SCHEMBL5105755 | 0.80 | CTSK (0.43) | POLBCTSKFFAR1ALDH1A1ECE2 | |
| SCHEMBL5105814 | 0.79 | DAGLB (0.39) | CTSKFFAR1HTR1AHTR7CTSL | |
| SCHEMBL6578142 | 0.77 | CTSK (0.48) | POLBCTSKKDM5CKDM4CKDM2A | |
| SCHEMBL5099441 | 0.76 | CTSK (0.49) | POLBCTSKKDM5CKDM4CKDM2A | |
| SCHEMBL6590094 | 0.73 | CTSK (0.47) | POLBCTSKKDM5CKDM4CKDM2A | |
| SCHEMBL4691175 | 0.73 | CTSK (0.47) | POLBCTSKKDM5CKDM4CKDM2A | |
| SCHEMBL7429714 | 0.73 | CTSK (0.64) | POLBCTSKKDM5CKDM4CKDM2A | |
| SCHEMBL5098711 | 0.73 | CTSK (0.64) | POLBCTSKKDM5CKDM4CKDM2A | |
| SCHEMBL6404534 | 0.73 | CTSK (0.64) | POLBCTSKKDM5CKDM4CKDM2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1158986-A4 | PROTEASE INHIBITORS | SMITHKLINE BEECHAM CORP (US) | 2002-03-27 | — | — | EP | claimed |
| EP-1158986-A1 | PROTEASE INHIBITORS | SmithKline Beecham Corporation (US) | 2001-12-05 | — | — | EP | claimed |
| WO-2000038687-A1 | PROTEASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2000-07-06 | — | — | WO | claimed |