Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 15/20 | 0.49 |
| ▸ | MMP9 | P14780 | 2/20 | 0.49 |
| ▸ | MMP12 | P39900 | 2/20 | 0.49 |
| ▸ | MMP3 | P08254 | 8/20 | 0.35 |
| ▸ | MMP1 | P03956 | 6/20 | 0.35 |
| ▸ | GPR84 | Q9NQS5 | 4/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | MMP7 | P09237 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7344022 | 0.92 | MMP2 (0.49) | MMP2MMP9MMP12MMP3MMP1 | |
| SCHEMBL7491884 | 0.87 | MMP2 (0.43) | MMP2MMP9MMP12 | |
| SCHEMBL7343586 | 0.80 | TDP2 (0.34) | ALDH1A1 | |
| SCHEMBL7486299 | 0.78 | MMP2 (0.49) | MMP2MMP9MMP12ALDH1A1 | |
| SCHEMBL7349021 | 0.76 | MMP2 (0.50) | MMP2MMP9MMP12MMP3MMP1 | |
| SCHEMBL7344018 | 0.76 | ALDH1A1 (0.56) | MMP2MMP9MMP12ALDH1A1 | |
| SCHEMBL7349674 | 0.73 | MMP2 (0.48) | MMP2MMP9MMP12MMP3MMP1 | |
| SCHEMBL7348992 | 0.72 | ATM (0.50) | ALDH1A1 | |
| SCHEMBL7349020 | 0.72 | MMP2 (0.50) | MMP2MMP9MMP12MMP3MMP1 | |
| SCHEMBL10979057 | 0.71 | MMP2 (0.78) | MMP2MMP9MMP12MMP3MMP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0509845-A1 | (+) and (-) enantiomers of 5-aliphatic-6-(benzoxazinyl- or benzothiazinyl)-2,3,4,5-tetrahydropyridazin-3-ones | ORTHO PHARMACEUTICAL CORPORATION (US) | 1992-10-21 | — | — | EP | disclosed |
| US-5081242-A | Cardiotonic and bronchodilator agents; phosphodiesterase inhibitors | ORTHO PHARMACEUTICAL CORPORATION (US) | 1992-01-14 | — | — | US | disclosed |
| US-4766118-A | CARDIOTONIC AGENTS, PHOSPHODIESTERASE INHIBITORS | ORTHO PHARMACEUTICAL CORPORATION (US) | 1988-08-23 | — | — | US | disclosed |
| EP-0272914-A2 | 6-Benzoxazinyl- and 6-benzothiazinyl-2,3,4,5-tetrahydropyridazin-3-ones | ORTHO PHARMACEUTICAL CORPORATION (US) | 1988-06-29 | — | — | EP | disclosed |