SCHEMBL7486384

SCHEMBL7486384

CCOCCC(C(=O)OCC)C(=O)OCC

nearest known ligand 0.47

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
TDP1 Q9NUW8 5/20 0.47
MEN1 O00255 2/20 0.47
KMT2A Q03164 2/20 0.47
ALDH1A1 P00352 6/20 0.46
TSHR P16473 3/20 0.46
L3MBTL1 Q9Y468 6/20 0.45
MAPK1 P28482 3/20 0.45
LMNA P02545 3/20 0.43
SMN1; SMN2 Q16637 1/20 0.43
POLB P06746 1/20 0.41
THRB P10828 1/20 0.41
MAPT P10636 2/20 0.40
CRHBP P24387 1/20 0.40
CRHR2 Q13324 1/20 0.40
HSD17B10 Q99714 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8331526 0.96 ALDH1A1 (0.48) TDP1MEN1KMT2AALDH1A1TSHR
SCHEMBL10850237 0.91 L3MBTL1 (0.49) TDP1MEN1KMT2AALDH1A1TSHR
SCHEMBL9518730 0.91 L3MBTL1 (0.49) TDP1MEN1KMT2AALDH1A1TSHR
SCHEMBL8330632 0.88 ALDH1A1 (0.41) TDP1MEN1KMT2AALDH1A1TSHR
SCHEMBL8329597 0.87 TDP1 (0.57) TDP1MEN1KMT2AALDH1A1TSHR
SCHEMBL8329625 0.85 ALDH1A1 (0.44) TDP1MEN1KMT2AALDH1A1TSHR
SCHEMBL24506841 0.85 ALDH1A1 (0.38) TDP1MEN1KMT2AALDH1A1TSHR
SCHEMBL17112876 0.84 MEN1 (0.50) TDP1MEN1KMT2AALDH1A1TSHR
SCHEMBL839632 0.84 L3MBTL1 (0.45) TDP1MEN1KMT2AALDH1A1TSHR
SCHEMBL8330184 0.84 TDP1 (0.54) TDP1MEN1KMT2AALDH1A1TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0966466-B1 PYRROLO 3,2-c]QUINOLINE DERIVATIVES CONTAINING HALOALKOXY GROUP AND PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF KOREA RES INST CHEM TECH (KR) 2002-07-03 EP claimed
EP-0966466-A1 PYRROLO 3,2-c]QUINOLINE DERIVATIVES CONTAINING HALOALKOXY GROUP AND PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY (KR) 1999-12-29 EP claimed
WO-1999009029-A1 PYRROLO[3,2-c]QUINOLINE DERIVATIVES CONTAINING HALOALKOXY GROUP AND PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY (KR) 1999-02-25 WO claimed
EP-0966466-B1 PYRROLO 3,2-c]QUINOLINE DERIVATIVES CONTAINING HALOALKOXY GROUP AND PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF KOREA RES INST CHEM TECH (KR) 2002-07-03 EP disclosed
US-6011044-A ANTIULCER AGENTS KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY (KR) 2000-01-04 US disclosed
EP-0966466-A1 PYRROLO 3,2-c]QUINOLINE DERIVATIVES CONTAINING HALOALKOXY GROUP AND PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY (KR) 1999-12-29 EP disclosed
US-5908863-A ANTIGROWTH AGENT FOR BONES DOMPE' S.P.A. (IT) 1999-06-01 US disclosed
WO-1999009029-A1 PYRROLO[3,2-c]QUINOLINE DERIVATIVES CONTAINING HALOALKOXY GROUP AND PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY (KR) 1999-02-25 WO disclosed
EP-0792878-A2 Geminal carboxylic acids and esters thereof, pharmaceutical formulations containing them useful in the treatment of bone dysmetabolism Dompé S.P.A. (IT) 1997-09-03 EP disclosed
EP-0307078-B1 QUINOLINE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM SMITHKLINE BEECHAM INTERCREDIT B.V. (NL) 1992-08-26 EP disclosed
US-5051508-A Antisecretory agents and enzyme inhibitors as antiulcer agents SMITHKLINE BECKMAN INTERCREDIT B.V. (NL) 1991-09-24 US disclosed
EP-0307078-A1 Quinoline derivatives, process for their preparation and pharmaceutical compositions containing them SMITHKLINE BEECHAM INTERCREDIT B.V. (NL) 1989-03-15 EP disclosed
US-4577023-A Diazabicyclo (2,2,2) octadiones STAMICARBON B.V. (NL) 1986-03-18 US disclosed
EP-0080245-A1 Diazabicyclo(2,2,2)octadiones and process for their preparation STAMICARBON B.V. (NL) 1983-06-01 EP disclosed