Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 9/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.51 |
| ▸ | HPGD | P15428 | 5/20 | 0.51 |
| ▸ | MAPT | P10636 | 3/20 | 0.51 |
| ▸ | GAA | P10253 | 5/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 4/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | GLA | P06280 | 2/20 | 0.43 |
| ▸ | MAOA | P21397 | 2/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | HTR2C | P28335 | 1/20 | 0.42 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.41 |
| ▸ | GFER | P55789 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | MAOB | P27338 | 2/20 | 0.40 |
| ▸ | UBE2N | P61088 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7475095 | 0.81 | KDM4E (0.47) | KDM4EALDH1A1HPGDMAPTGAA | |
| SCHEMBL4390489 | 0.76 | KDM4E (0.79) | KDM4EALDH1A1HPGDMAPTGAA | |
| SCHEMBL29116625 | 0.75 | KDM4E (0.77) | KDM4EALDH1A1HPGDMAPTGAA | |
| SCHEMBL7824982 | 0.70 | LMNA (0.62) | KDM4EALDH1A1HPGDMAPTGAA | |
| SCHEMBL11313571 | 0.68 | KDM4E (0.66) | KDM4EALDH1A1HPGDMAPTGAA | |
| SCHEMBL11309411 | 0.68 | KDM4E (1.00) | KDM4EALDH1A1HPGDMAPTGAA | |
| SCHEMBL6898974 | 0.68 | KDM4E (0.70) | KDM4EALDH1A1HPGDMAPTGAA | |
| SCHEMBL660817 | 0.67 | ALDH1A1 (0.80) | KDM4EALDH1A1HPGDMAPTGAA | |
| SCHEMBL5312406 | 0.67 | KDM4E (0.68) | KDM4EALDH1A1HPGDMAPTGAA | |
| SCHEMBL6865603 | 0.67 | KDM4E (0.64) | KDM4EALDH1A1HPGDMAPTGLA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1144417-B1 | 4'-SUBSTITUTED-4',5'-DIHYDROPSORALENS AND THERAPEUTICAL USES THEREOF | BUCKMAN LABOR INC (US) | 2002-09-04 | — | — | EP | disclosed |
| EP-1144417-A1 | 4'-SUBSTITUTED-4',5'-DIHYDROPSORALENS AND THERAPEUTICAL USES THEREOF | BUCKMAN LABORATORIES INTERNATIONAL, INC. (US) | 2001-10-17 | — | — | EP | disclosed |
| US-6177424-B1 | ANTIPROLIFERATIVE AGENTS, MICROBIOCIDES, ANTISEPTICS | HEINDEL NED D (US) | 2001-01-23 | — | — | US | disclosed |
| WO-2000032603-A1 | 4'-SUBSTITUTED-4',5'-DIHYDROPSORALENS AND THERAPEUTICAL USES THEREOF | BUCKMAN LABORATORIES INTERNATIONAL, INC. (US) | 2000-06-08 | — | — | WO | disclosed |