Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.47 |
| ▸ | HPGD | P15428 | 4/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | GAA | P10253 | 4/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.40 |
| ▸ | MAOA | P21397 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | HTR2C | P28335 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | ALPL | P05186 | 2/20 | 0.38 |
| ▸ | ALPI | P09923 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7486500 | 0.81 | KDM4E (0.51) | KDM4EALDH1A1HPGDMAPTGAA | |
| SCHEMBL7479194 | 0.74 | MCL1 (0.56) | KDM4EALDH1A1HPGDMAPTGAA | |
| SCHEMBL4390489 | 0.73 | KDM4E (0.79) | KDM4EALDH1A1HPGDMAPTGAA | |
| SCHEMBL27742426 | 0.72 | CYP1A2 (0.41) | KDM4EALDH1A1HPGDCYP1A2CYP3A4 | |
| SCHEMBL17320634 | 0.68 | CYP3A4 (0.42) | KDM4EALDH1A1HPGDMAPTL3MBTL1 | |
| SCHEMBL5647436 | 0.67 | GPR35 (0.40) | KDM4EALDH1A1HPGDMAPTL3MBTL1 | |
| SCHEMBL10872882 | 0.67 | ALDH1A1 (0.42) | ALDH1A1HPGDMAPTGAAL3MBTL1 | |
| SCHEMBL7824982 | 0.67 | LMNA (0.62) | KDM4EALDH1A1HPGDMAPTGAA | |
| SCHEMBL26982525 | 0.65 | MAPT (0.37) | KDM4EALDH1A1HPGDMAPTL3MBTL1 | |
| SCHEMBL11313571 | 0.65 | KDM4E (0.66) | KDM4EALDH1A1HPGDMAPTGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1144417-B1 | 4'-SUBSTITUTED-4',5'-DIHYDROPSORALENS AND THERAPEUTICAL USES THEREOF | BUCKMAN LABOR INC (US) | 2002-09-04 | — | — | EP | disclosed |
| EP-1144417-A1 | 4'-SUBSTITUTED-4',5'-DIHYDROPSORALENS AND THERAPEUTICAL USES THEREOF | BUCKMAN LABORATORIES INTERNATIONAL, INC. (US) | 2001-10-17 | — | — | EP | disclosed |
| US-6177424-B1 | ANTIPROLIFERATIVE AGENTS, MICROBIOCIDES, ANTISEPTICS | HEINDEL NED D (US) | 2001-01-23 | — | — | US | disclosed |
| WO-2000032603-A1 | 4'-SUBSTITUTED-4',5'-DIHYDROPSORALENS AND THERAPEUTICAL USES THEREOF | BUCKMAN LABORATORIES INTERNATIONAL, INC. (US) | 2000-06-08 | — | — | WO | disclosed |