Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | TP53 | P04637 | 2/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.39 |
| ▸ | MAPT | P10636 | 4/20 | 0.39 |
| ▸ | HPGD | P15428 | 4/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.36 |
| ▸ | CLK2 | P49760 | 1/20 | 0.36 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7478966 | 0.84 | HSD17B10 (0.43) | SMN1; SMN2NPC1RAB9ATP53HSD17B10 | |
| SCHEMBL7476196 | 0.81 | KDM4E (0.40) | SMN1; SMN2NPC1RAB9ATP53HSD17B10 | |
| SCHEMBL7473993 | 0.81 | ADORA3 (0.41) | SMN1; SMN2NPC1RAB9ATP53HSD17B10 | |
| SCHEMBL7478340 | 0.78 | ALDH1A1 (0.40) | SMN1; SMN2HSD17B10KDM4EALDH1A1MAPT | |
| SCHEMBL7485545 | 0.77 | ALDH1A1 (0.45) | SMN1; SMN2NPC1RAB9ATP53KDM4E | |
| SCHEMBL8034969 | 0.77 | SMN1; SMN2 (0.40) | SMN1; SMN2NPC1RAB9ATP53HSD17B10 | |
| SCHEMBL8044065 | 0.76 | HSD17B10 (0.47) | SMN1; SMN2NPC1RAB9ATP53HSD17B10 | |
| SCHEMBL7479151 | 0.74 | CHRM4 (0.44) | SMN1; SMN2HSD17B10KDM4EALDH1A1LMNA | |
| SCHEMBL7481507 | 0.73 | KDM4E (0.53) | SMN1; SMN2RAB9AHSD17B10KDM4EALDH1A1 | |
| SCHEMBL7470768 | 0.72 | KDM4E (0.46) | SMN1; SMN2NPC1RAB9ATP53HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0883622-B1 | PROTON PUMP INHIBITOR | APOTEX INC (CA) | 2002-05-15 | — | — | EP | disclosed |
| US-6114537-A | 1,2,4-THIADIAZOLE COMPOUND IS USEFUL FOR TRAPPING THIOL COMPOUNDS AND SELECTIVELY CHANGING THIOLS TO DISULFIDE COMPOUNDS | APOTEX INC. (CA) | 2000-09-05 | — | — | US | disclosed |
| US-6093738-A | IMIDAZO(1,2-D)-THIADIAZOLE COMPOUNDS; PEPTIC ULCER TREATMENT | KARIMIAN KHASHAYAR (CA) | 2000-07-25 | — | — | US | disclosed |
| US-5677302-A | Thiadiazole compounds useful as proton pump inhibitors | APOTEX INC. (CA) | 1997-10-14 | — | — | US | disclosed |