SCHEMBL7487137

SCHEMBL7487137

COc1ccc2c(c1)C(=O)N(Nc1ncccc1C)C(=O)C2

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 6/20 0.49
HPGD P15428 3/20 0.49
GAA P10253 2/20 0.49
CYP1A2 P05177 2/20 0.49
CYP3A4 P08684 2/20 0.49
CYP2C9 P11712 2/20 0.49
CYP2C19 P33261 2/20 0.49
L3MBTL1 Q9Y468 2/20 0.49
KDM4E B2RXH2 2/20 0.49
KMT2A Q03164 4/20 0.48
MEN1 O00255 3/20 0.48
SMN1; SMN2 Q16637 4/20 0.48
CASP1 P29466 1/20 0.47
NPC1 O15118 4/20 0.41
RAB9A P51151 4/20 0.41
MAPT P10636 1/20 0.40
ALOX12 P18054 1/20 0.40
GRM4 Q14833 1/20 0.40
METAP1 P53582 1/20 0.39
CASP6 P55212 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7487129 0.89 ALDH1A1 (0.55) ALDH1A1HPGDGAACYP1A2CYP3A4
SCHEMBL7489425 0.88 ALDH1A1 (0.48) ALDH1A1HPGDGAACYP1A2CYP3A4
SCHEMBL7476799 0.78 ALDH1A1 (0.51) ALDH1A1HPGDGAACYP1A2CYP3A4
Hydrochloric Acid SCHEMBL8418434 0.76 ALDH1A1 (0.49) ALDH1A1HPGDGAACYP1A2CYP3A4
Hydrochloric Acid SCHEMBL8418433 0.76 ALDH1A1 (0.49) ALDH1A1HPGDGAACYP1A2CYP3A4
Hydrochloric Acid SCHEMBL7482266 0.76 ALDH1A1 (0.48) ALDH1A1HPGDGAACYP1A2CYP3A4
SCHEMBL9922254 0.69 ALDH1A1 (0.63) ALDH1A1HPGDGAACYP1A2CYP3A4
SCHEMBL13495344 0.68 ALDH1A1 (0.62) ALDH1A1HPGDGAACYP1A2CYP3A4
SCHEMBL7487924 0.65 CASP6 (0.51) ALDH1A1HPGDGAACYP1A2KMT2A
SCHEMBL6295643 0.62 MEN1 (0.71) KMT2AMEN1NPC1RAB9AMAOA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0950056-B1 N-(PYRIDINYLAMINO)ISOINDOLINES AND RELATED COMPOUNDS AVENTIS PHARMA INC (US) 2002-09-18 EP claimed
EP-0950056-B1 N-(PYRIDINYLAMINO)ISOINDOLINES AND RELATED COMPOUNDS AVENTIS PHARMA INC (US) 2002-09-18 EP disclosed
US-6004977-A ANTIDEPRESSANTS, COGNITION ACTIVATORS, AND ALZHEIMER'S DISEASE TREATMENT HOECHST MARION ROUSSEL, INC. (US) 1999-12-21 US disclosed
EP-0950056-A2 N-(PYRIDINYLAMINO)ISOINDOLINES AND RELATED COMPOUNDS HOECHST MARION ROUSSEL, INC. (US) 1999-10-20 EP disclosed
WO-1998029407-A2 N-(PYRIDINYLAMINO)ISOINDOLINES FOR TREATING ALZHEIMER'S AND DEPRESSION HOECHST MARION ROUSSEL, INC. (US) 1998-07-09 WO disclosed