Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.51 |
| ▸ | HPGD | P15428 | 3/20 | 0.51 |
| ▸ | GAA | P10253 | 2/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | CASP1 | P29466 | 1/20 | 0.48 |
| ▸ | CASP6 | P55212 | 1/20 | 0.48 |
| ▸ | CYP19A1 | P11511 | 8/20 | 0.44 |
| ▸ | METAP1 | P53582 | 2/20 | 0.43 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.41 |
| ▸ | ADAM17 | P78536 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL8418434 | 0.98 | ALDH1A1 (0.49) | ALDH1A1HPGDGAAKDM4ECYP1A2 | |
| Hydrochloric Acid SCHEMBL8418433 | 0.98 | ALDH1A1 (0.49) | ALDH1A1HPGDGAAKDM4ECYP1A2 | |
| Hydrochloric Acid SCHEMBL7482266 | 0.96 | ALDH1A1 (0.48) | ALDH1A1HPGDGAAKDM4ECYP1A2 | |
| SCHEMBL7487924 | 0.84 | CASP6 (0.51) | ALDH1A1HPGDGAACYP1A2KMT2A | |
| SCHEMBL8860233 | 0.82 | CYP19A1 (0.43) | ALDH1A1HPGDKMT2AMEN1SMN1; SMN2 | |
| SCHEMBL7479666 | 0.82 | APP (0.46) | ALDH1A1CYP1A2SMN1; SMN2CYP19A1LMNA | |
| SCHEMBL7486935 | 0.81 | CASP6 (0.51) | KDM4ECYP1A2CASP6CYP19A1LMNA | |
| SCHEMBL7479829 | 0.81 | CASP6 (0.51) | KDM4EKMT2AMEN1CASP6LMNA | |
| Hydrochloric Acid SCHEMBL7485356 | 0.81 | APP (0.45) | ALDH1A1CYP1A2SMN1; SMN2CYP19A1LMNA | |
| SCHEMBL7487129 | 0.78 | ALDH1A1 (0.55) | ALDH1A1HPGDGAAKDM4ECYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0950056-A2 | N-(PYRIDINYLAMINO)ISOINDOLINES AND RELATED COMPOUNDS | HOECHST MARION ROUSSEL, INC. (US) | 1999-10-20 | — | — | EP | claimed |
| WO-1998029407-A2 | N-(PYRIDINYLAMINO)ISOINDOLINES FOR TREATING ALZHEIMER'S AND DEPRESSION | HOECHST MARION ROUSSEL, INC. (US) | 1998-07-09 | — | — | WO | claimed |
| EP-0950056-B1 | N-(PYRIDINYLAMINO)ISOINDOLINES AND RELATED COMPOUNDS | AVENTIS PHARMA INC (US) | 2002-09-18 | — | — | EP | disclosed |
| EP-0950056-A2 | N-(PYRIDINYLAMINO)ISOINDOLINES AND RELATED COMPOUNDS | HOECHST MARION ROUSSEL, INC. (US) | 1999-10-20 | — | — | EP | disclosed |
| WO-1998029407-A2 | N-(PYRIDINYLAMINO)ISOINDOLINES FOR TREATING ALZHEIMER'S AND DEPRESSION | HOECHST MARION ROUSSEL, INC. (US) | 1998-07-09 | — | — | WO | disclosed |