Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA3 | P0DMS8 | 4/20 | 0.51 |
| ▸ | ADORA1 | P30542 | 4/20 | 0.51 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | TP53 | P04637 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.36 |
| ▸ | BRD4 | O60885 | 1/20 | 0.35 |
| ▸ | BRD9 | Q9H8M2 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7487204 | 1.00 | ADORA3 (0.51) | ADORA3ADORA1MEN1KMT2AHSD17B10 | |
| SCHEMBL7479242 | 0.71 | CYP1A2 (0.41) | ADORA3ADORA1TP53KDM4EEGFR | |
| SCHEMBL7479237 | 0.71 | CYP1A2 (0.41) | ADORA3ADORA1TP53KDM4EEGFR | |
| SCHEMBL8314453 | 0.71 | ADORA3 (0.52) | ADORA3ADORA1MEN1KMT2AHSD17B10 | |
| SCHEMBL8315158 | 0.70 | ALDH1A1 (0.51) | ADORA3ADORA1MEN1KMT2AALDH1A1 | |
| SCHEMBL8316652 | 0.69 | ADORA3 (0.50) | ADORA3ADORA1MEN1KMT2AHSD17B10 | |
| SCHEMBL7474399 | 0.66 | CYP1A2 (0.59) | MEN1KMT2ANPC1ALDH1A1RAB9A | |
| SCHEMBL7474407 | 0.66 | CYP1A2 (0.59) | MEN1KMT2ANPC1ALDH1A1RAB9A | |
| SCHEMBL7482662 | 0.66 | CYP1A2 (0.47) | NPC1ALDH1A1RAB9AHPGDNPSR1 | |
| SCHEMBL7478196 | 0.65 | ALDH1A1 (0.34) | MEN1KMT2AHSD17B10NPC1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0742218-B1 | PYRROLOPYRIDAZINE DERIVATIVE | SANKYO CO (JP) | 2002-12-04 | — | — | EP | disclosed |
| US-6063782-A | Pyrrolopyridazine derivatives | SANKYO COMPANY, LIMITED (JP) | 2000-05-16 | — | — | US | disclosed |
| EP-0742218-A1 | PYRROLOPYRIDAZINE DERIVATIVE | SANKYO COMPANY LIMITED (JP) | 1996-11-13 | — | — | EP | disclosed |