Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA3 | P0DMS8 | 4/20 | 0.50 |
| ▸ | ADORA1 | P30542 | 4/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | RAD52 | P43351 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | AR | P10275 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8314453 | 0.84 | ADORA3 (0.52) | ADORA3ADORA1MEN1KMT2ATP53 | |
| SCHEMBL8315158 | 0.81 | ALDH1A1 (0.51) | ADORA3ADORA1MEN1KMT2ATP53 | |
| SCHEMBL8315989 | 0.77 | CYP1A2 (0.43) | POLBALDH1A1NPSR1KDM4ETSHR | |
| SCHEMBL4590906 | 0.72 | CYP3A4 (0.52) | LMNAPOLBSMN1; SMN2ALDH1A1HPGD | |
| SCHEMBL9737913 | 0.70 | FABP4 (0.43) | ADORA3ADORA1MEN1KMT2ATP53 | |
| Hydrochloric Acid SCHEMBL1738613 | 0.69 | FABP4 (0.47) | MEN1KMT2ALMNAPOLBSMN1; SMN2 | |
| SCHEMBL7487204 | 0.69 | ADORA3 (0.51) | ADORA3ADORA1MEN1KMT2ATP53 | |
| SCHEMBL7487200 | 0.69 | ADORA3 (0.51) | ADORA3ADORA1MEN1KMT2ATP53 | |
| SCHEMBL1735938 | 0.68 | MCL1 (0.45) | LMNAPOLBSMN1; SMN2ALDH1A1NPSR1 | |
| SCHEMBL8313968 | 0.67 | ALDH1A1 (0.42) | LMNASMN1; SMN2ALDH1A1KDM4ETSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0609328-B1 | PYRROLO-PYRIDAZINES WITH GASTRO-INTESTINAL PROTECTIVE ACTION | BYK GULDEN LOMBERG CHEM FAB (DE) | 1999-04-28 | — | — | EP | disclosed |
| US-5534515-A | Pyrrolopyridazines having gastrointestinal protective effects | BYK GULDEN LOMBERG CHEMISCHE FABRIK GMBH (DE) | 1996-07-09 | — | — | US | disclosed |
| WO-1993008190-A1 | PYRROLO-PYRIDAZINES WITH GASTRO-INTESTINAL PROTECTIVE ACTION | BYK GULDEN LOMBERG CHEMISCHE FABRIK GMBH (DE) | 1993-04-29 | — | — | WO | disclosed |