Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G10 | O15496 | 1/20 | 0.43 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.38 |
| ▸ | HTR3B | O95264 | 1/20 | 0.38 |
| ▸ | HTR3A | P46098 | 1/20 | 0.38 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.38 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.38 |
| ▸ | KAT6A | Q92794 | 1/20 | 0.38 |
| ▸ | CES2 | O00748 | 1/20 | 0.38 |
| ▸ | P2RX1 | P51575 | 1/20 | 0.38 |
| ▸ | CNR2 | P34972 | 2/20 | 0.37 |
| ▸ | PTGIR | P43119 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | PARP1 | P09874 | 1/20 | 0.36 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | KIF11 | P52732 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27721413 | 0.85 | P2RX1 (0.43) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| SCHEMBL7642079 | 0.85 | GRIK1 (0.47) | PLA2G10PTGIRKMT2APARP1GRIK1 | |
| SCHEMBL27515597 | 0.82 | NPSR1 (0.42) | KMT2AMEN1MAPTHTTRAB9A | |
| SCHEMBL5606524 | 0.82 | CES2 (0.50) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| SCHEMBL27742328 | 0.81 | P2RX1 (0.44) | CES2P2RX1KMT2AGRIK1MEN1 | |
| SCHEMBL27742325 | 0.81 | TMPRSS4 (0.47) | P2RX1KMT2AGRIK1MEN1 | |
| SCHEMBL27721342 | 0.81 | HSD17B1 (0.45) | P2RX1MAPTHTTALDH1A1 | |
| SCHEMBL28217598 | 0.81 | PTGIR (0.46) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| SCHEMBL7609217 | 0.80 | MEN1 (0.50) | P2RX1KMT2AGRIK1MEN1ALDH1A1 | |
| SCHEMBL27742332 | 0.79 | KIF11 (0.53) | P2RX1KMT2AMEN1MAPTHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0896531-A4 | IL-8 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORP (US) | 2002-10-30 | — | — | EP | disclosed |
| EP-0896531-A1 | IL-8 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 1999-02-17 | — | — | EP | disclosed |
| WO-1997029743-A1 | IL-8 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 1997-08-21 | — | — | WO | disclosed |