Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 | P08172 | 5/20 | 0.65 |
| ▸ | CHRM3 | P20309 | 5/20 | 0.65 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.53 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.50 |
| ▸ | ARG1 | P05089 | 2/20 | 0.48 |
| ▸ | ARG2 | P78540 | 2/20 | 0.48 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL924276 | 0.78 | OPRM1 (0.77) | CHRM2CHRM3OPRD1SIGMAR1MEN1 | |
| SCHEMBL2212897 | 0.77 | CHRM2 (0.55) | CHRM2CHRM3OPRD1SIGMAR1MEN1 | |
| SCHEMBL8569723 | 0.76 | CHRM2 (0.70) | CHRM2CHRM3OPRD1SIGMAR1MEN1 | |
| SCHEMBL7497962 | 0.75 | GAA (0.60) | CHRM2CHRM3SIGMAR1MEN1KMT2A | |
| SCHEMBL7312986 | 0.74 | SMN1; SMN2 (0.68) | SIGMAR1MEN1KMT2ASMN1; SMN2KDM4E | |
| SCHEMBL3775423 | 0.74 | OPRD1 (0.54) | CHRM2CHRM3OPRD1SIGMAR1SMN1; SMN2 | |
| SCHEMBL6312739 | 0.74 | SIGMAR1 (0.76) | SIGMAR1MEN1KMT2ASMN1; SMN2KDM4E | |
| SCHEMBL3150313 | 0.73 | SMN1; SMN2 (0.65) | SIGMAR1MEN1KMT2ASMN1; SMN2KDM4E | |
| SCHEMBL6105478 | 0.73 | CHRM2 (0.52) | CHRM2CHRM3OPRD1SIGMAR1MEN1 | |
| SCHEMBL12511819 | 0.73 | SIGMAR1 (0.70) | SIGMAR1MEN1KMT2ASMN1; SMN2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1212299-A1 | SUBSTITUTED PIPERIDINE COMPOUNDS USEFUL AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY | AstraZeneca UK Limited (GB) | 2002-06-12 | — | — | EP | disclosed |
| WO-2001014333-A1 | SUBSTITUTED PIPERIDINE COMPOUNDS USEFUL AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY | ASTRAZENECA UK LIMITED (GB) | 2001-03-01 | — | — | WO | disclosed |