SCHEMBL7487338

SCHEMBL7487338

Cc1[c]nc2cccnc2c1

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 5/20 0.41
NPC1 O15118 3/20 0.38
HSP90AA1 P07900 1/20 0.38
L3MBTL1 Q9Y468 1/20 0.38
PRMT5 O14744 1/20 0.37
KDM4E B2RXH2 3/20 0.37
MAPT P10636 2/20 0.37
ATAD2 Q6PL18 1/20 0.36
POLB P06746 1/20 0.35
RAB9A P51151 1/20 0.35
CCR1 P32246 1/20 0.35
CCR8 P51685 1/20 0.35
PDGFRB P09619 1/20 0.35
PDGFRA P16234 1/20 0.35
NQO2 P16083 1/20 0.34
GAA P10253 1/20 0.34
MEN1 O00255 1/20 0.33
CASP1 P29466 1/20 0.33
CASP7 P55210 1/20 0.33
KMT2A Q03164 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2996821 0.72 ALDH1A1 (0.36) ALDH1A1NPC1HSP90AA1KDM4EMAPT
SCHEMBL7085947 0.72 ALDH1A1 (0.36) ALDH1A1NPC1HSP90AA1KDM4EMAPT
SCHEMBL521935 0.71 NQO2 (0.46) ALDH1A1NPC1L3MBTL1KDM4EMAPT
SCHEMBL7387228 0.71 CCR1 (0.42) ALDH1A1NPC1HSP90AA1L3MBTL1KDM4E
SCHEMBL130023 0.67 CYP1A2 (0.55) ALDH1A1PRMT5KDM4EMAPTATAD2
SCHEMBL12596682 0.67 ALDH1A1 (0.46) ALDH1A1NPC1HSP90AA1L3MBTL1PRMT5
SCHEMBL2519761 0.67 HSP90AA1 (0.41) ALDH1A1NPC1HSP90AA1L3MBTL1PRMT5
SCHEMBL1100332 0.67 ALDH1A1 (0.58) ALDH1A1NPC1HSP90AA1KDM4EMAPT
SCHEMBL8194 0.67 ALDH1A1 (0.67) ALDH1A1NPC1HSP90AA1KDM4EMAPT
SCHEMBL30099834 0.67 ALDH1A1 (0.67) ALDH1A1NPC1HSP90AA1KDM4EMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1204663-A1 NOVEL SPIRO COMPOUNDS BANYU PHARMACEUTICAL CO., LTD. (JP) 2002-05-15 EP disclosed
WO-2001014376-A1 NOVEL SPIRO COMPOUNDS BANYU PHARMACEUTICAL CO., LTD. (JP) 2001-03-01 WO disclosed