Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.36 |
| ▸ | TOP1 | P11387 | 2/20 | 0.35 |
| ▸ | OGA | O60502 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.33 |
| ▸ | CLK1 | P49759 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.31 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.31 |
| ▸ | CASP1 | P29466 | 2/20 | 0.31 |
| ▸ | HTT | P42858 | 2/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | CASP7 | P55210 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5250342 | 0.74 | MAPT (0.41) | ALDH1A1KDM4EMAPTNPC1POLB | |
| SCHEMBL7487338 | 0.72 | ALDH1A1 (0.41) | ALDH1A1KDM4EMAPTNPC1POLB | |
| SCHEMBL2996821 | 0.71 | ALDH1A1 (0.36) | ALDH1A1KDM4EMAPTNPC1POLB | |
| SCHEMBL5798966 | 0.67 | NPC1 (0.47) | ALDH1A1TOP1KDM4EMAPTNPC1 | |
| SCHEMBL2519761 | 0.63 | HSP90AA1 (0.41) | ALDH1A1TOP1KDM4EMAPTNPC1 | |
| SCHEMBL30099834 | 0.63 | ALDH1A1 (0.67) | ALDH1A1KDM4EMAPTNPC1POLB | |
| SCHEMBL8194 | 0.63 | ALDH1A1 (0.67) | ALDH1A1KDM4EMAPTNPC1POLB | |
| SCHEMBL177791 | 0.62 | HCAR2 (0.30) | HCAR2 | |
| SCHEMBL2407261 | 0.62 | MAPT (0.40) | ALDH1A1KDM4EMAPTRAB9AMEN1 | |
| Hydrochloric Acid SCHEMBL3710107 | 0.61 | ALDH1A1 (0.63) | ALDH1A1KDM4EMAPTNPC1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20030220499-A1 | Novel spiro compounds | MSD K.K. (JP) | 2003-11-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030220499-A1 | Novel spiro compounds | NPY1R, OPRK1, OPRM1 | ALDH1A1 1230/4885TOP1 2327/4885OGA 2489/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.