Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.52 |
| ▸ | PIM1 | P11309 | 1/20 | 0.45 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.45 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.45 |
| ▸ | CKS1B | P61024 | 1/20 | 0.45 |
| ▸ | SKP1 | P63208 | 1/20 | 0.45 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.45 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.44 |
| ▸ | KDM4D | Q6B0I6 | 2/20 | 0.44 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.42 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.42 |
| ▸ | SUV39H2 | Q9H5I1 | 2/20 | 0.42 |
| ▸ | NPY5R | Q15761 | 4/20 | 0.42 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.41 |
| ▸ | CTSK | P43235 | 2/20 | 0.41 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.41 |
| ▸ | CHRNB4 | P30926 | 2/20 | 0.41 |
| ▸ | CHRNA3 | P32297 | 2/20 | 0.41 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4827630 | 0.91 | GPR119 (0.60) | GPR119PIM1PIM3PIM2CKS1B | |
| SCHEMBL28856276 | 0.91 | GPR119 (0.60) | GPR119PIM1PIM3PIM2CKS1B | |
| SCHEMBL28200582 | 0.91 | GPR119 (0.60) | GPR119PIM1PIM3PIM2CKS1B | |
| SCHEMBL4954837 | 0.86 | GPR119 (0.65) | GPR119CKS1BSKP1SKP2PDE10A | |
| SCHEMBL29576692 | 0.85 | GPR119 (0.55) | GPR119CKS1BSKP1SKP2PDE10A | |
| SCHEMBL22774285 | 0.85 | GPR119 (0.55) | GPR119CKS1BSKP1SKP2PDE10A | |
| SCHEMBL22775604 | 0.85 | GPR119 (0.55) | GPR119CKS1BSKP1SKP2PDE10A | |
| SCHEMBL29576568 | 0.85 | GPR119 (0.55) | GPR119CKS1BSKP1SKP2PDE10A | |
| SCHEMBL21847896 | 0.83 | GPR119 (0.55) | GPR119CKS1BSKP1SKP2PDE10A | |
| SCHEMBL23500781 | 0.79 | CKS1B (0.56) | GPR119PIM1PIM3PIM2CKS1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1178982-A1 | HETEROCYCLIC SUBSTITUTED AMINOAZACYCLES USEFUL AS CENTRAL NERVOUS SYSTEM AGENTS | ABBOTT LABORATORIES (US) | 2002-02-13 | — | — | EP | disclosed |
| WO-2000071534-A1 | HETEROCYCLIC SUBSTITUTED AMINOAZACYCLES USEFUL AS CENTRAL NERVOUS SYSTEM AGENTS | ABBOTT LABORATORIES (US) | 2000-11-30 | — | — | WO | disclosed |