Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 4/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.50 |
| ▸ | USP2 | O75604 | 2/20 | 0.50 |
| ▸ | KEAP1 | Q14145 | 2/20 | 0.50 |
| ▸ | NFE2L2 | Q16236 | 2/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | APP | P05067 | 6/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.42 |
| ▸ | CASP3 | P42574 | 1/20 | 0.41 |
| ▸ | TERT | O14746 | 3/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30937815 | 0.84 | MEN1 (0.55) | MEN1KMT2AUSP2KEAP1NFE2L2 | |
| SCHEMBL127059 | 0.84 | MEN1 (0.55) | MEN1KMT2AUSP2KEAP1NFE2L2 | |
| SCHEMBL11533449 | 0.80 | L3MBTL1 (0.47) | MEN1KMT2AUSP2KEAP1NFE2L2 | |
| SCHEMBL13285362 | 0.78 | MEN1 (0.50) | MEN1KMT2AUSP2KEAP1NFE2L2 | |
| SCHEMBL11530531 | 0.77 | PRMT1 (0.45) | MEN1KMT2AUSP2L3MBTL1NPC1 | |
| SCHEMBL9968958 | 0.76 | TERT (0.56) | MEN1KMT2AUSP2KEAP1NFE2L2 | |
| SCHEMBL12170761 | 0.76 | TERT (0.56) | MEN1KMT2AUSP2KEAP1NFE2L2 | |
| SCHEMBL9968962 | 0.76 | TERT (0.56) | MEN1KMT2AUSP2KEAP1NFE2L2 | |
| SCHEMBL710594 | 0.76 | TERT (0.56) | MEN1KMT2AUSP2KEAP1NFE2L2 | |
| SCHEMBL24453229 | 0.74 | MEN1 (0.47) | MEN1KMT2AUSP2KEAP1NFE2L2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1141140-B1 | NAPHTHALENEHYDRAZAMIMIDES AND PERYLENEHYDRAZAMIMIDES | CIBA SC HOLDING AG (CH) | 2002-09-04 | — | — | EP | disclosed |
| EP-1141140-A1 | NAPHTHALENEHYDRAZAMIMIDES AND PERYLENEHYDRAZAMIMIDES | Ciba SC Holding AG (CH) | 2001-10-10 | — | — | EP | disclosed |
| US-6143890-A | Naphthalenehydrazamimides and perylenehydrazamimides | CIBA SPECIALTY CHEMICALS CORPORATION (US) | 2000-11-07 | — | — | US | disclosed |
| WO-2000040657-A1 | NAPHTHALENEHYDRAZAMIMIDES AND PERYLENEHYDRAZAMIMIDES | CIBA SPECIALTY CHEMICALS HOLDING INC. (CH) | 2000-07-13 | — | — | WO | disclosed |