Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 | Q14145 | 2/20 | 0.52 |
| ▸ | NFE2L2 | Q16236 | 2/20 | 0.52 |
| ▸ | USP2 | O75604 | 1/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | CCR2 | P41597 | 1/20 | 0.46 |
| ▸ | IKBKB | O14920 | 1/20 | 0.46 |
| ▸ | SLC40A1 | Q9NP59 | 1/20 | 0.45 |
| ▸ | METAP2 | P50579 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | MPI | P34949 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7487670 | 1.00 | KEAP1 (0.52) | KEAP1NFE2L2USP2TDP1NPSR1 | |
| SCHEMBL7488003 | 0.91 | KEAP1 (0.53) | KEAP1NFE2L2USP2TDP1NPSR1 | |
| SCHEMBL7488011 | 0.91 | KEAP1 (0.53) | KEAP1NFE2L2USP2TDP1NPSR1 | |
| SCHEMBL7482719 | 0.89 | KDM4E (0.50) | KEAP1NFE2L2USP2TDP1NPSR1 | |
| SCHEMBL7482712 | 0.89 | KDM4E (0.50) | KEAP1NFE2L2USP2TDP1NPSR1 | |
| SCHEMBL6172083 | 0.84 | ERBB2 (0.57) | KEAP1NFE2L2CCR2LMNAMAPT | |
| SCHEMBL6172085 | 0.84 | ERBB2 (0.57) | KEAP1NFE2L2CCR2LMNAMAPT | |
| SCHEMBL7493057 | 0.84 | METAP2 (0.58) | KEAP1NFE2L2NPSR1METAP2ALDH1A1 | |
| SCHEMBL7493052 | 0.84 | METAP2 (0.58) | KEAP1NFE2L2NPSR1METAP2ALDH1A1 | |
| SCHEMBL7482984 | 0.84 | MEN1 (0.52) | KEAP1NFE2L2USP2CCR2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1065206-B1 | Tetrazolylalkyl indole compounds as anti-inflammatory and analgesic agents | PFIZER (US) | 2002-10-09 | — | — | EP | disclosed |
| EP-1065206-A1 | Tetrazolylalkyl indole compounds as anti-inflammatory and analgesic agents | PFIZER INC. (US) | 2001-01-03 | — | — | EP | disclosed |