Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 5/20 | 0.53 |
| ▸ | HRH3 | Q9Y5N1 | 5/20 | 0.51 |
| ▸ | DRD2 | P14416 | 3/20 | 0.49 |
| ▸ | HTR2A | P28223 | 3/20 | 0.49 |
| ▸ | MAOB | P27338 | 3/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | HTR7 | P34969 | 2/20 | 0.47 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.47 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.47 |
| ▸ | CNR1 | P21554 | 1/20 | 0.47 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.47 |
| ▸ | HTR2C | P28335 | 1/20 | 0.47 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.47 |
| ▸ | HRH1 | P35367 | 1/20 | 0.47 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7485995 | 0.99 | HTR1A (0.54) | HTR1AHRH3DRD2HTR2AMAOB | |
| SCHEMBL7491899 | 0.88 | HTR1A (0.54) | HTR1ADRD2CYP1A2CYP2C9SIGMAR1 | |
| Fumaric Acid SCHEMBL7488720 | 0.87 | HRH3 (0.49) | HTR1AHRH3DRD2HTR2AMAOB | |
| Fumaric Acid SCHEMBL7488718 | 0.87 | HRH3 (0.49) | HTR1AHRH3DRD2HTR2AMAOB | |
| SCHEMBL7483822 | 0.87 | HRH3 (0.42) | HTR1AHRH3DRD2HTR2AMAOB | |
| SCHEMBL7484406 | 0.86 | HRH3 (0.42) | HTR1AHRH3DRD2HTR2AMAOB | |
| SCHEMBL7488133 | 0.81 | HTR1A (0.50) | HTR1AHRH3ALDH1A1HTR7DRD3 | |
| Fumaric Acid SCHEMBL7489724 | 0.81 | HRH3 (0.42) | HTR1AHRH3DRD2MAOBDRD3 | |
| Fumaric Acid SCHEMBL7490162 | 0.81 | HRH3 (0.42) | HTR1AHRH3DRD2MAOBDRD3 | |
| Fumaric Acid SCHEMBL7488585 | 0.80 | HRH3 (0.41) | HTR1AHRH3DRD2HTR2AMAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1023287-B1 | 3-OXO-2(H)-1,2,4-TRIAZINE DERIVATIVES AS LIGANDS OF 5HT1A RECEPTORS | PF MEDICAMENT (FR) | 2002-06-12 | — | — | EP | claimed |
| US-6303603-B1 | FOR THEARPY OF ANXIETY, DEPRESSION, SCHIZOPHRENIA | PIERRE FABRE MEDICAMENT (FR) | 2001-10-16 | — | — | US | claimed |
| EP-1023287-A1 | 3-OXO-2(H)-1,2,4-TRIAZINE DERIVATIVES AS LIGANDS OF 5HT1A RECEPTORS | PIERRE FABRE MEDICAMENT (FR) | 2000-08-02 | — | — | EP | claimed |
| WO-1999020622-A1 | 3-OXO-2(H)-1,2,4-TRIAZINE DERIVATIVES AS LIGANDS OF 5HT1A RECEPTORS | PIERRE FABRE MEDICAMENT (FR) | 1999-04-29 | — | — | WO | claimed |
| EP-1023287-B1 | 3-OXO-2(H)-1,2,4-TRIAZINE DERIVATIVES AS LIGANDS OF 5HT1A RECEPTORS | PF MEDICAMENT (FR) | 2002-06-12 | — | — | EP | disclosed |
| US-6303603-B1 | FOR THEARPY OF ANXIETY, DEPRESSION, SCHIZOPHRENIA | PIERRE FABRE MEDICAMENT (FR) | 2001-10-16 | — | — | US | disclosed |
| EP-1023287-A1 | 3-OXO-2(H)-1,2,4-TRIAZINE DERIVATIVES AS LIGANDS OF 5HT1A RECEPTORS | PIERRE FABRE MEDICAMENT (FR) | 2000-08-02 | — | — | EP | disclosed |
| WO-1999020622-A1 | 3-OXO-2(H)-1,2,4-TRIAZINE DERIVATIVES AS LIGANDS OF 5HT1A RECEPTORS | PIERRE FABRE MEDICAMENT (FR) | 1999-04-29 | — | — | WO | disclosed |