Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ATP4AATP4BAXLBTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CHRM2CHRM3CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4FLT3HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3KCNH2KMT2AMAP2K1MAP2K2MEN1MLNRMPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PLK4PPARGRENS1PR1SLC6A2SLC6A3SLC6A4SMOTYK2atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 known ✓ | Q9Y5N1 | 6/20 | 0.41 |
| ▸ | HTR1A known ✓ | P08908 | 2/20 | 0.38 |
| ▸ | HTR2A known ✓ | P28223 | 2/20 | 0.38 |
| ▸ | HTR2C known ✓ | P28335 | 1/20 | 0.38 |
| ▸ | DRD2 known ✓ | P14416 | 1/20 | 0.37 |
| ▸ | MAOB | P27338 | 3/20 | 0.39 |
| ▸ | DRD3 | P35462 | 3/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | DRD4 | P21917 | 2/20 | 0.37 |
| ▸ | ACHE | P22303 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL7488578 | 1.00 | HRH3 (0.41) | HRH3MAOBDRD3HTR1AHTR2A | |
| Fumaric Acid SCHEMBL7489724 | 0.90 | HRH3 (0.42) | HRH3MAOBDRD3HTR1AKDM4E | |
| Fumaric Acid SCHEMBL7490162 | 0.90 | HRH3 (0.42) | HRH3MAOBDRD3HTR1AKDM4E | |
| Fumaric Acid SCHEMBL7488718 | 0.86 | HRH3 (0.49) | HRH3MAOBDRD3HTR1AHTR2A | |
| Fumaric Acid SCHEMBL7488720 | 0.86 | HRH3 (0.49) | HRH3MAOBDRD3HTR1AHTR2A | |
| Fumaric Acid SCHEMBL7492264 | 0.84 | HRH3 (0.38) | HRH3MAOBHTR1AKDM4EACHE | |
| Fumaric Acid SCHEMBL7492260 | 0.84 | HRH3 (0.38) | HRH3MAOBHTR1AKDM4EACHE | |
| Fumaric Acid SCHEMBL7491971 | 0.83 | DRD2 (0.45) | DRD3HTR1AHTR2AKDM4EALDH1A1 | |
| Fumaric Acid SCHEMBL7491977 | 0.83 | DRD2 (0.45) | DRD3HTR1AHTR2AKDM4EALDH1A1 | |
| SCHEMBL7484406 | 0.81 | HRH3 (0.42) | HRH3MAOBDRD3HTR1AHTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1023287-B1 | 3-OXO-2(H)-1,2,4-TRIAZINE DERIVATIVES AS LIGANDS OF 5HT1A RECEPTORS | PF MEDICAMENT (FR) | 2002-06-12 | — | — | EP | claimed |
| US-6303603-B1 | FOR THEARPY OF ANXIETY, DEPRESSION, SCHIZOPHRENIA | PIERRE FABRE MEDICAMENT (FR) | 2001-10-16 | — | — | US | claimed |
| EP-1023287-B1 | 3-OXO-2(H)-1,2,4-TRIAZINE DERIVATIVES AS LIGANDS OF 5HT1A RECEPTORS | PF MEDICAMENT (FR) | 2002-06-12 | — | — | EP | disclosed |
| US-6303603-B1 | FOR THEARPY OF ANXIETY, DEPRESSION, SCHIZOPHRENIA | PIERRE FABRE MEDICAMENT (FR) | 2001-10-16 | — | — | US | disclosed |