Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 3/20 | 0.54 |
| ▸ | SIGMAR1 | Q99720 | 8/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | DRD2 | P14416 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7485995 | 0.89 | HTR1A (0.54) | HTR1ASIGMAR1KDM4ECYP1A2CYP2C9 | |
| SCHEMBL7483822 | 0.88 | HRH3 (0.42) | HTR1ASIGMAR1DRD2 | |
| SCHEMBL7488037 | 0.88 | HTR1A (0.53) | HTR1ASIGMAR1KDM4ECYP1A2CYP2C9 | |
| SCHEMBL7484406 | 0.81 | HRH3 (0.42) | HTR1ADRD2 | |
| Fumaric Acid SCHEMBL7488720 | 0.78 | HRH3 (0.49) | HTR1ADRD2 | |
| Fumaric Acid SCHEMBL7488718 | 0.78 | HRH3 (0.49) | HTR1ADRD2 | |
| Fumaric Acid SCHEMBL7492264 | 0.78 | HRH3 (0.38) | HTR1AKDM4E | |
| Fumaric Acid SCHEMBL7492260 | 0.78 | HRH3 (0.38) | HTR1AKDM4E | |
| SCHEMBL14761486 | 0.77 | DRD2 (0.60) | HTR1ASIGMAR1KDM4ECYP1A2CYP2C9 | |
| SCHEMBL7489563 | 0.77 | HRH3 (0.49) | HTR1ADRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1023287-B1 | 3-OXO-2(H)-1,2,4-TRIAZINE DERIVATIVES AS LIGANDS OF 5HT1A RECEPTORS | PF MEDICAMENT (FR) | 2002-06-12 | — | — | EP | claimed |
| US-6303603-B1 | FOR THEARPY OF ANXIETY, DEPRESSION, SCHIZOPHRENIA | PIERRE FABRE MEDICAMENT (FR) | 2001-10-16 | — | — | US | claimed |
| EP-1023287-B1 | 3-OXO-2(H)-1,2,4-TRIAZINE DERIVATIVES AS LIGANDS OF 5HT1A RECEPTORS | PF MEDICAMENT (FR) | 2002-06-12 | — | — | EP | disclosed |
| US-6303603-B1 | FOR THEARPY OF ANXIETY, DEPRESSION, SCHIZOPHRENIA | PIERRE FABRE MEDICAMENT (FR) | 2001-10-16 | — | — | US | disclosed |
| EP-1023287-A1 | 3-OXO-2(H)-1,2,4-TRIAZINE DERIVATIVES AS LIGANDS OF 5HT1A RECEPTORS | PIERRE FABRE MEDICAMENT (FR) | 2000-08-02 | — | — | EP | disclosed |
| WO-1999020622-A1 | 3-OXO-2(H)-1,2,4-TRIAZINE DERIVATIVES AS LIGANDS OF 5HT1A RECEPTORS | PIERRE FABRE MEDICAMENT (FR) | 1999-04-29 | — | — | WO | disclosed |