Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 4/20 | 0.34 |
| ▸ | ADORA2B | P29275 | 3/20 | 0.34 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.34 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.34 |
| ▸ | XDH | P47989 | 1/20 | 0.33 |
| ▸ | TLR7 | Q9NYK1 | 2/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | SPNS2 | Q8IVW8 | 1/20 | 0.32 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.32 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.32 |
| ▸ | CHRM5 | P08912 | 2/20 | 0.32 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.32 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.32 |
| ▸ | PDE4A | P27815 | 1/20 | 0.31 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.31 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.31 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.31 |
| ▸ | CNR1 | P21554 | 1/20 | 0.30 |
| ▸ | CNR2 | P34972 | 1/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7492084 | 0.99 | ADORA2A (0.35) | ADORA2AADORA2BADORA1ADORA3XDH | |
| SCHEMBL7487478 | 0.94 | ADORA2A (0.34) | ADORA2AADORA2BADORA1ADORA3XDH | |
| SCHEMBL7489579 | 0.90 | ADORA2A (0.32) | ADORA2AADORA2BADORA1PDE4APDE4B | |
| SCHEMBL7492011 | 0.77 | CYP19A1 (0.40) | ADORA2BTLR7 | |
| SCHEMBL7492889 | 0.77 | CHRM2 (0.34) | ADORA2BKCNH2SPNS2CHRM2CHRM4 | |
| SCHEMBL7488243 | 0.76 | ADORA2B (0.40) | ADORA2AADORA2BTLR7 | |
| SCHEMBL7486698 | 0.76 | TSHR (0.41) | ADORA2AADORA2BADORA1KCNH2KDM4E | |
| SCHEMBL7488311 | 0.76 | TSHR (0.41) | ADORA2AADORA2BADORA1KCNH2KDM4E | |
| SCHEMBL7492422 | 0.75 | CHRM2 (0.32) | ADORA2AADORA2BADORA1ADORA3KCNH2 | |
| SCHEMBL7491743 | 0.74 | TSHR (0.41) | ADORA2AADORA2BADORA1KCNH2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0915093-B1 | AMIDE DERIVATIVES | OTSUKA PHARMA CO LTD (JP) | 2002-11-27 | — | — | EP | disclosed |
| US-6166016-A | Amide derivatives | OTSUKA PHARMACEUTICAL FACTORY, INC. (JP) | 2000-12-26 | — | — | US | disclosed |
| EP-0915093-A1 | AMIDE DERIVATIVES | OTSUKA PHARMACEUTICAL FACTORY, INC. (JP) | 1999-05-12 | — | — | EP | disclosed |