Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 5/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.44 |
| ▸ | MMP1 | P03956 | 1/20 | 0.41 |
| ▸ | MMP3 | P08254 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | BLM | P54132 | 1/20 | 0.40 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | FDPS | P14324 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7491428 | 0.80 | HDAC3 (0.40) | KMT2ACYP1A2CYP2C19POLBALDH1A1 | |
| SCHEMBL7484970 | 0.72 | MEN1 (0.47) | HRH3MEN1KMT2ACYP1A2CYP3A4 | |
| SCHEMBL7484977 | 0.72 | CASP1 (0.50) | MEN1KMT2AATMALDH1A1 | |
| SCHEMBL2456964 | 0.70 | HRH3 (0.50) | HRH3MEN1KMT2ACYP1A2CYP3A4 | |
| SCHEMBL6946483 | 0.68 | MEN1 (0.46) | HRH3MEN1KMT2ACYP1A2CYP3A4 | |
| SCHEMBL7497814 | 0.68 | CYP1A2 (0.47) | HRH3MEN1KMT2ACYP1A2CYP3A4 | |
| SCHEMBL7492782 | 0.68 | KMT2A (0.62) | MEN1KMT2APOLBMAPTALDH1A1 | |
| SCHEMBL7497820 | 0.67 | NPC1 (0.47) | MEN1KMT2AATMMAPTALDH1A1 | |
| SCHEMBL28417577 | 0.67 | PPARG (0.55) | MEN1KMT2ACYP1A2ALDH1A1RAB9A | |
| Hydrochloric Acid SCHEMBL27734857 | 0.66 | KMT2A (0.60) | MEN1KMT2APOLBMAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6462042-B1 | TUMOR NECROSIS FACTOR ALPHA CONVERTING ENZYME INHIBITORS; INFLAMMATORY DISEASES, AUTOIMMUNE DISEASES, CANCER, CARDIO-VASCULAR DISEASES, RHEUMATOID ARTHRITIS, OSTEOARTHRITIS, OSTEOPOROSIS, NEURODEGENERATION, ALZHEIMER'S DISEASE, STROKE | DARWIN DISCOVERY LIMITED (GB) | 2002-10-08 | — | — | US | claimed |
| EP-1237867-A1 | HYDROXAMIC ACID DERIVATIVES AS MATRIX METALLOPROTEINASE (MMP) INHIBITORS | Darwin Discovery Limited (GB) | 2002-09-11 | — | — | EP | claimed |
| WO-2001044188-A1 | HYDROXAMIC ACID DERIVATIVES AS MATRIX METALLOPROTEINASE (MMP) INHIBITORS | DARWIN DISCOVERY LIMITED (GB) | 2001-06-21 | — | — | WO | claimed |
| US-6462042-B1 | TUMOR NECROSIS FACTOR ALPHA CONVERTING ENZYME INHIBITORS; INFLAMMATORY DISEASES, AUTOIMMUNE DISEASES, CANCER, CARDIO-VASCULAR DISEASES, RHEUMATOID ARTHRITIS, OSTEOARTHRITIS, OSTEOPOROSIS, NEURODEGENERATION, ALZHEIMER'S DISEASE, STROKE | DARWIN DISCOVERY LIMITED (GB) | 2002-10-08 | — | — | US | disclosed |