Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC3 | O15379 | 1/20 | 0.40 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.40 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.40 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.40 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.40 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.40 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.40 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 3/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | FDPS | P14324 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7488762 | 0.80 | HRH3 (0.44) | CYP1A2CYP2C19POLBFDPSKMT2A | |
| SCHEMBL7493044 | 0.72 | TACR1 (0.42) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL7493051 | 0.72 | ALDH1A1 (0.58) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL6847096 | 0.70 | HDAC1 (0.65) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL9374769 | 0.68 | CYP1A2 (0.51) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL7493128 | 0.67 | EPHX2 (0.40) | FDPSLMNAALOX5RAB9AKCNH2 | |
| SCHEMBL6241724 | 0.67 | CYP1A2 (0.57) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL7493136 | 0.66 | ALDH1A1 (0.50) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL12418966 | 0.65 | PPARA (0.45) | FDPSALOX5ALDH1A1PPARGPPARA | |
| SCHEMBL8142471 | 0.64 | SLC6A4 (0.57) | POLBKMT2ASLC6A4SLC6A3FFAR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6462042-B1 | TUMOR NECROSIS FACTOR ALPHA CONVERTING ENZYME INHIBITORS; INFLAMMATORY DISEASES, AUTOIMMUNE DISEASES, CANCER, CARDIO-VASCULAR DISEASES, RHEUMATOID ARTHRITIS, OSTEOARTHRITIS, OSTEOPOROSIS, NEURODEGENERATION, ALZHEIMER'S DISEASE, STROKE | DARWIN DISCOVERY LIMITED (GB) | 2002-10-08 | — | — | US | claimed |
| EP-1237867-A1 | HYDROXAMIC ACID DERIVATIVES AS MATRIX METALLOPROTEINASE (MMP) INHIBITORS | Darwin Discovery Limited (GB) | 2002-09-11 | — | — | EP | claimed |
| WO-2001044188-A1 | HYDROXAMIC ACID DERIVATIVES AS MATRIX METALLOPROTEINASE (MMP) INHIBITORS | DARWIN DISCOVERY LIMITED (GB) | 2001-06-21 | — | — | WO | claimed |
| US-6462042-B1 | TUMOR NECROSIS FACTOR ALPHA CONVERTING ENZYME INHIBITORS; INFLAMMATORY DISEASES, AUTOIMMUNE DISEASES, CANCER, CARDIO-VASCULAR DISEASES, RHEUMATOID ARTHRITIS, OSTEOARTHRITIS, OSTEOPOROSIS, NEURODEGENERATION, ALZHEIMER'S DISEASE, STROKE | DARWIN DISCOVERY LIMITED (GB) | 2002-10-08 | — | — | US | disclosed |