Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 5/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.45 |
| ▸ | HPGD | P15428 | 4/20 | 0.45 |
| ▸ | RPS6KB2 | Q9UBS0 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | ITGB2 | P05107 | 1/20 | 0.43 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.43 |
| ▸ | ITGAL | P20701 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7488800 | 1.00 | ALDH1A1 (0.51) | ALDH1A1HSD17B10TDP1MAPTKDM4E | |
| SCHEMBL7490702 | 1.00 | ALDH1A1 (0.51) | ALDH1A1HSD17B10TDP1MAPTKDM4E | |
| SCHEMBL7485148 | 0.84 | MAPT (0.48) | ALDH1A1HSD17B10TDP1MAPTKDM4E | |
| SCHEMBL7487013 | 0.84 | MAPT (0.48) | ALDH1A1HSD17B10TDP1MAPTKDM4E | |
| SCHEMBL7485154 | 0.84 | MAPT (0.48) | ALDH1A1HSD17B10TDP1MAPTKDM4E | |
| SCHEMBL6100693 | 0.81 | CYP4F2 (0.46) | ALDH1A1HSD17B10TDP1MAPTKDM4E | |
| SCHEMBL6100697 | 0.81 | CYP4F2 (0.46) | ALDH1A1HSD17B10TDP1MAPTKDM4E | |
| SCHEMBL7483507 | 0.81 | CYP4F2 (0.46) | ALDH1A1HSD17B10TDP1MAPTKDM4E | |
| SCHEMBL9259508 | 0.80 | CYP3A4 (0.47) | ALDH1A1MAPTHPGDRPS6KB2POLB | |
| SCHEMBL25368025 | 0.78 | CA2 (0.47) | ALDH1A1MAPTKDM4EHPGDRPS6KB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0825189-B1 | 1,4-BENZODIOXIN DERIVATIVES | NISSHIN PHARMA INC (JP) | 2002-01-02 | — | — | EP | disclosed |
| US-6130243-A | PROPHYLACTIC OR THERAPEUTIC AGENT FOR DIABETES, HYPERGLYCEMIA AND OBESITY IN MAMMALS | NISSHIN FLOUR MILLING CO., LTD. (JP) | 2000-10-10 | — | — | US | disclosed |
| EP-0825189-A1 | 1,4-BENZODIOXIN DERIVATIVES | NISSHIN FLOUR MILLING CO., LTD. (JP) | 1998-02-25 | — | — | EP | disclosed |