Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LIPE | Q05469 | 7/20 | 0.61 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.44 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.44 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.44 |
| ▸ | MAOA | P21397 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7479368 | 0.84 | LIPE (0.68) | LIPENOTUMMEN1KMT2AMAPT | |
| SCHEMBL7456919 | 0.83 | LIPE (0.61) | LIPENOTUMMEN1KMT2AMAPT | |
| SCHEMBL11881512 | 0.83 | LIPE (0.61) | LIPENOTUMMEN1KMT2AMAPT | |
| SCHEMBL14890641 | 0.80 | LIPE (0.62) | LIPEKMT2AMAPTNPC1TP53 | |
| SCHEMBL14907228 | 0.79 | LIPE (0.66) | LIPEMEN1KMT2ASMN1; SMN2GAA | |
| SCHEMBL9109432 | 0.78 | SMN1; SMN2 (0.60) | LIPEMEN1KMT2AMAPTNPC1 | |
| SCHEMBL7549708 | 0.76 | LIPE (1.00) | LIPENOTUMNPC1TP53RAB9A | |
| SCHEMBL5672647 | 0.76 | LIPE (0.55) | LIPENOTUMMEN1KMT2AMAPT | |
| SCHEMBL14907137 | 0.75 | LIPE (0.55) | LIPEMEN1KMT2AMAPTNPC1 | |
| SCHEMBL11269986 | 0.75 | KEAP1 (0.59) | LIPEKMT2AMAPTSMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0950056-B1 | N-(PYRIDINYLAMINO)ISOINDOLINES AND RELATED COMPOUNDS | AVENTIS PHARMA INC (US) | 2002-09-18 | — | — | EP | disclosed |
| US-6004977-A | ANTIDEPRESSANTS, COGNITION ACTIVATORS, AND ALZHEIMER'S DISEASE TREATMENT | HOECHST MARION ROUSSEL, INC. (US) | 1999-12-21 | — | — | US | disclosed |