Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AHR | P35869 | 2/20 | 0.46 |
| ▸ | SMYD3 | Q9H7B4 | 6/20 | 0.44 |
| ▸ | GRIA1 | P42261 | 2/20 | 0.43 |
| ▸ | CACNG8 | Q8WXS5 | 2/20 | 0.43 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.42 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.42 |
| ▸ | MAOB | P27338 | 3/20 | 0.41 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.40 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | PGR | P06401 | 1/20 | 0.40 |
| ▸ | EIF2AK2 | P19525 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL689457 | 0.73 | MAOB (0.62) | AHRGRIA1CACNG8PDE3BPDE3A | |
| SCHEMBL578518 | 0.70 | AHR (0.56) | AHRSMYD3GRIA1CACNG8PDE3B | |
| SCHEMBL7121335 | 0.70 | AHR (0.56) | AHRSMYD3GRIA1CACNG8PDE3B | |
| SCHEMBL6829825 | 0.70 | TDP1 (0.49) | EPHX2TDP1 | |
| SCHEMBL10714519 | 0.70 | PDE3B (0.57) | AHRGRIA1CACNG8PDE3BPDE3A | |
| SCHEMBL261651 | 0.69 | SMYD3 (0.57) | AHRSMYD3EPHX2GAA | |
| SCHEMBL9407115 | 0.69 | TDP1 (0.45) | EPHX2TDP1 | |
| SCHEMBL7349900 | 0.68 | AHR (0.53) | AHRSMYD3GRIA1CACNG8PDE3B | |
| SCHEMBL10375833 | 0.68 | MAOB (0.65) | AHRPDE3BPDE3AMAOBEIF2AK2 | |
| SCHEMBL433708 | 0.68 | AHR (0.61) | AHRGRIA1CACNG8PDE3BPDE3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1224169-A2 | PRODUCTION OF 5-SUBSTITUTED INDOLINONES AND USE THEREOF AS MEDICAMENTS | Boehringer Ingelheim Pharma KG (DE) | 2002-07-24 | — | — | EP | disclosed |
| WO-2001027080-A2 | 5-SUBSTITUTED INDOLINONES AND USE THEREOF AS KINASE AND CYCLIN/CDK COMPLEX INHIBITORS | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2001-04-19 | — | — | WO | disclosed |