Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCB1 | P08183 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | PKM | P14618 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | AVPR1B | P47901 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | MMP2 | P08253 | 2/20 | 0.40 |
| ▸ | MMP8 | P22894 | 2/20 | 0.40 |
| ▸ | MMP12 | P39900 | 2/20 | 0.40 |
| ▸ | MMP13 | P45452 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6610253 | 0.84 | ABCB1 (0.51) | ABCB1MAPTTSHRPOLBSMN1; SMN2 | |
| SCHEMBL7489125 | 0.81 | ABCB1 (0.49) | ABCB1MAPTTSHRPOLBSMN1; SMN2 | |
| SCHEMBL6610090 | 0.74 | SNCA (0.47) | MAPTPOLBSMN1; SMN2NPC1LMNA | |
| SCHEMBL5656436 | 0.73 | LMNA (0.48) | MAPTPOLBNPC1LMNAKMT2A | |
| SCHEMBL8628089 | 0.71 | MAPT (0.60) | MAPTTSHRPOLBSMN1; SMN2NPC1 | |
| SCHEMBL6609938 | 0.69 | MAPT (0.48) | MAPTPOLBNPC1LMNAALDH1A1 | |
| SCHEMBL6612494 | 0.69 | TAS2R14 (0.46) | ABCB1MAPTNPC1LMNAALDH1A1 | |
| SCHEMBL6608937 | 0.69 | MEN1 (0.47) | ABCB1MAPTPOLBSMN1; SMN2NPC1 | |
| SCHEMBL6611082 | 0.68 | LMNA (0.42) | MAPTPOLBLMNAKMT2AKDM4E | |
| SCHEMBL5656058 | 0.67 | POLB (0.48) | MAPTPOLBALDH1A1KMT2AMMP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1147095-A1 | 2, 3, 4, 5-TETRAHYDRO-1H-[1, 4] BENZODIAZEPINE-3-HYDROXAMIC ACIDS AS MATRIX METALLOPROTEINASE INHIBITORS | American Cyanamid Company (US) | 2001-10-24 | — | — | EP | disclosed |
| WO-2000044730-A1 | 2,3,4,5-TETRAHYDRO-1H-[1,4]BENZODIAZEPINE-3-HYDROXAMIC ACID AS MATRIX METALLOPROTEINASE INHIBITORS | AMERICAN CYANAMID COMPANY (US) | 2000-08-03 | — | — | WO | disclosed |