Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | PPARG | P37231 | 1/20 | 0.31 |
| ▸ | PPARD | Q03181 | 1/20 | 0.31 |
| ▸ | PPARA | Q07869 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7494741 | 0.70 | GABRA1 (0.34) | POLB | |
| SCHEMBL17748186 | 0.67 | — | — | |
| SCHEMBL17681681 | 0.67 | — | — | |
| SCHEMBL10986339 | 0.66 | XDH (0.31) | POLBALDH1A1PPARGPPARD | |
| SCHEMBL23699844 | 0.65 | TNKS (0.30) | — | |
| SCHEMBL1624906 | 0.65 | TDP1 (0.48) | POLBALDH1A1PPARGPPARDPPARA | |
| SCHEMBL18094957 | 0.65 | DPP4 (0.42) | ALDH1A1 | |
| SCHEMBL7494750 | 0.64 | CYP3A4 (0.49) | POLBALDH1A1PPARGPPARDPPARA | |
| SCHEMBL10751466 | 0.64 | CYP3A4 (0.53) | POLBALDH1A1PPARGPPARDPPARA | |
| SCHEMBL10989483 | 0.64 | XDH (0.35) | ALDH1A1PPARGPPARD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1173170-A4 | PYRROLIDINE MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY | MERCK & CO INC (US) | 2002-05-29 | — | — | EP | disclosed |
| EP-1173170-A1 | PYRROLIDINE MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY | Merck & Co., Inc. (US) | 2002-01-23 | — | — | EP | disclosed |
| US-6265434-B1 | ANTIINFLAMMATORY AGENTS | MERCK & CO., INC. | 2001-07-24 | — | — | US | disclosed |
| WO-2000059503-A1 | PYRROLIDINE MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY | MERCK & CO., INC. (US) | 2000-10-12 | — | — | WO | disclosed |