Sugi Predict

Sugi Predict / Compounds / Hydroxyamine

Hydroxyamine

Hydroxyamine

SCHEMBL7489267

CC#CCOc1ccc(S(=O)(=O)N2CCN(C(=O)N3CCOCC3)CC2C(=O)O)cc1.NO

nearest known ligand 0.60

Full drug profile on Sugi Atlas →

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
▸ MMP13 P45452 20/20 0.60
▸ ADAM17 P78536 19/20 0.60
▸ MMP1 P03956 18/20 0.60
▸ MMP9 P14780 8/20 0.60
▸ MMP3 P08254 1/20 0.57
▸ MMP7 P09237 1/20 0.57

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6501269 0.98 MMP13 (0.61) MMP13ADAM17MMP1MMP9MMP3
SCHEMBL6506638 0.89 MMP13 (0.59) MMP13ADAM17MMP1MMP9MMP3
SCHEMBL3942611 0.89 MMP13 (0.77) MMP13ADAM17MMP1MMP9MMP3
SCHEMBL7442494 0.86 MMP13 (0.69) MMP13ADAM17MMP1MMP9
SCHEMBL6506731 0.85 MMP13 (0.80) MMP13ADAM17MMP1MMP9
SCHEMBL6506041 0.83 MMP13 (0.80) MMP13ADAM17MMP1MMP9MMP3
SCHEMBL6506359 0.82 MMP13 (0.71) MMP13ADAM17MMP1MMP9
SCHEMBL6501341 0.81 ADAM17 (0.64) MMP13ADAM17MMP1MMP9MMP3
SCHEMBL7470367 0.80 MMP13 (0.64) MMP13ADAM17MMP1MMP9
SCHEMBL3942022 0.80 MMP13 (0.81) MMP13ADAM17MMP1MMP9MMP3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1144368-A2 ACETYLENIC ALPHA-AMINO ACID-BASED SULFONAMIDE HYDROXAMIC ACID TACE INHIBITORS American Cyanamid Company (US) 2001-10-17 — — EP disclosed
WO-2000044709-A2 ACETYLENIC α-AMINO ACID-BASED SULFONAMIDE HYDROXAMIC ACID TACE INHIBITORS AMERICAN CYANAMID COMPANY (US) 2000-08-03 — — WO disclosed