Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Morphine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 known ✓ | P35372 | 8/20 | 0.81 |
| ▸ | OPRD1 | P41143 | 9/20 | 0.81 |
| ▸ | OPRK1 | P41145 | 6/20 | 0.81 |
| ▸ | MRGPRX2 | Q96LB1 | 2/20 | 0.81 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.81 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.81 |
| ▸ | ARRB1 | P49407 | 1/20 | 0.81 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Morphine SCHEMBL6459790 | 0.94 | OPRD1 (0.82) | OPRD1OPRM1OPRK1MRGPRX2SLC22A1 | |
| Morphine SCHEMBL6433223 | 0.94 | OPRD1 (0.82) | OPRD1OPRM1OPRK1MRGPRX2SLC22A1 | |
| Morphine SCHEMBL8374708 | 0.91 | OPRD1 (0.90) | OPRD1OPRM1OPRK1MRGPRX2SLC22A1 | |
| Morphine SCHEMBL15055206 | 0.91 | OPRD1 (0.90) | OPRD1OPRM1OPRK1MRGPRX2SLC22A1 | |
| Morphine SCHEMBL149700 | 0.91 | OPRD1 (0.90) | OPRD1OPRM1OPRK1MRGPRX2SLC22A1 | |
| Morphine SCHEMBL2443249 | 0.90 | OPRD1 (0.89) | OPRD1OPRM1OPRK1MRGPRX2SLC22A1 | |
| Morphine SCHEMBL27557022 | 0.90 | OPRD1 (0.89) | OPRD1OPRM1OPRK1MRGPRX2SLC22A1 | |
| Morphine SCHEMBL27547724 | 0.90 | OPRD1 (0.96) | OPRD1OPRM1OPRK1MRGPRX2SLC22A1 | |
| Morphine SCHEMBL24599520 | 0.90 | OPRD1 (1.00) | OPRD1OPRM1OPRK1MRGPRX2SLC22A1 | |
| Morphine SCHEMBL12125412 | 0.90 | OPRD1 (1.00) | OPRD1OPRM1OPRK1MRGPRX2SLC22A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1017696-B1 | ACIDIC ADDITION SALTS OF MORPHINE ALKALOIDS AND THE APPLICATION THEREOF | LOHMANN THERAPIE SYST LTS (DE) | 2002-03-20 | — | — | EP | disclosed |
| EP-1017696-A1 | ACIDIC ADDITION SALTS OF MORPHINE ALKALOIDS AND THE APPLICATION THEREOF | LTS Lohmann Therapie-Systeme AG (DE) | 2000-07-12 | — | — | EP | disclosed |
| WO-1999015528-A1 | ACIDIC ADDITION SALTS OF MORPHINE ALKALOIDS AND THE APPLICATION THEREOF | LTS LOHMANN THERAPIE-SYSTEME AG (DE) | 1999-04-01 | — | — | WO | disclosed |