SCHEMBL7490519

SCHEMBL7490519

CC(C)=N/N=C1\NC(=O)C(CCCCNC(=O)OCc2ccccc2)N1

nearest known ligand 0.49

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
IDO1 P14902 1/20 0.49
TDO2 P48775 1/20 0.49
TPSAB1 Q15661 3/20 0.49
HTT P42858 1/20 0.46
KEAP1 Q14145 3/20 0.45
NFE2L2 Q16236 3/20 0.45
TGM2 P21980 1/20 0.44
LMNA P02545 1/20 0.42
SMN1; SMN2 Q16637 1/20 0.42
L3MBTL1 Q9Y468 2/20 0.41
MAPT P10636 1/20 0.41
FOLH1 Q04609 3/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7490523 1.00 IDO1 (0.49) IDO1TDO2TPSAB1HTTKEAP1
SCHEMBL7490465 0.83 TPSAB1 (0.38) TPSAB1MAPT
SCHEMBL7490470 0.83 TPSAB1 (0.38) TPSAB1MAPT
SCHEMBL8766141 0.82 IDO1 (0.57) IDO1TDO2TPSAB1HTTKEAP1
SCHEMBL17368069 0.82 TPSAB1 (0.62) IDO1TDO2TPSAB1HTTKEAP1
SCHEMBL11922749 0.82 TPSAB1 (0.62) IDO1TDO2TPSAB1HTTKEAP1
SCHEMBL27286441 0.81 HTT (0.46) IDO1TDO2TPSAB1HTTKEAP1
SCHEMBL15044828 0.79 TPSAB1 (0.57) IDO1TDO2TPSAB1HTTKEAP1
SCHEMBL7491614 0.79 GLA (0.50) IDO1TDO2L3MBTL1
SCHEMBL7491608 0.79 GLA (0.50) IDO1TDO2L3MBTL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0638075-B1 THIAZOLE OR IMIDAZOLE DERIVATIVES AS MAILLARD REACTION INHIBITORS OTSUKA PHARMA CO LTD (JP) 2002-01-16 EP claimed
EP-0638075-B1 THIAZOLE OR IMIDAZOLE DERIVATIVES AS MAILLARD REACTION INHIBITORS OTSUKA PHARMA CO LTD (JP) 2002-01-16 EP disclosed
WO-1998043649-A2 AGE PRODUCTION INHIBITORY COMPOSITION COMPRISING A MAILLARD REACTION INHIBITOR AND VITAMIN B¿6? OTSUKA PHARMACEUTICAL CO., LTD. (JP) 1998-10-08 WO disclosed
US-5677322-A THERAPY FOR AGING, DIABETES OTSUKA PHARMACEUTICAL CO., LTD. (JP) 1997-10-14 US disclosed
EP-0638075-A1 THIAZOLE OR IMIDAZOLE DERIVATIVES AS MAILLARD REACTION INHIBITORS OTSUKA PHARMACEUTICAL CO., LTD. (JP) 1995-02-15 EP disclosed
WO-1994019335-A1 THIAZOLE OR IMIDAZOLE DERIVATIVES AS MAILLARD REACTION INHIBITORS OTSUKA PHARMACEUTICAL CO., LTD. (JP) 1994-09-01 WO disclosed