Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.36 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7495596 | 0.70 | MAPK1 (0.63) | KMT2ASMN1; SMN2POLBALDH1A1LMNA | |
| SCHEMBL14777735 | 0.68 | KDM4E (0.33) | — | |
| SCHEMBL7489361 | 0.68 | GRM4 (0.39) | KMT2ASMN1; SMN2ALDH1A1LMNAPKM | |
| SCHEMBL2673470 | 0.65 | PIK3C3 (0.43) | KMT2AALDH1A1LMNAHTTMEN1 | |
| SCHEMBL7243871 | 0.64 | CA12 (0.44) | KMT2ASMN1; SMN2ALDH1A1LMNAMAPK1 | |
| SCHEMBL11645949 | 0.63 | SLC9A1 (0.41) | KMT2APOLBMEN1L3MBTL1TDP1 | |
| SCHEMBL15742051 | 0.61 | ABCB1 (0.39) | KMT2ASMN1; SMN2ALDH1A1LMNAHTT | |
| SCHEMBL11699453 | 0.60 | PSIP1 (0.53) | SMN1; SMN2POLBALDH1A1HTTTP53 | |
| SCHEMBL29493433 | 0.60 | KMT2A (0.49) | KMT2ASMN1; SMN2POLBALDH1A1LMNA | |
| SCHEMBL11644146 | 0.60 | SLC9A1 (0.44) | KMT2ASMN1; SMN2POLBALDH1A1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0783499-B1 | BENZOFURAN DERIVATIVES AS TACHYKININ ANTAGONISTS | GLAXO GROUP LTD (GB) | 2002-10-23 | — | — | EP | disclosed |
| US-5935972-A | Benzofuran derivatives as tachykinin antagonists | GLAXO GROUP LIMITED (GB) | 1999-08-10 | — | — | US | disclosed |
| EP-0783499-A1 | BENZOFURAN DERIVATIVES AS TACHYKININ ANTAGONISTS | GLAXO GROUP LIMITED (GB) | 1997-07-16 | — | — | EP | disclosed |
| WO-1995006645-A1 | BENZOFURAN DERIVATIVES AS TACHYKININ ANTAGONISTS | GLAXO GROUP LIMITED (GB) | 1995-03-09 | — | — | WO | disclosed |