Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM4 | Q14833 | 8/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | PSIP1 | O75475 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | PARL | Q9H300 | 1/20 | 0.33 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.32 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.32 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.32 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1384870 | 0.88 | GRM4 (0.43) | GRM4PKMMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL692875 | 0.77 | — | — | |
| SCHEMBL7244739 | 0.73 | GAA (0.44) | GRM4GAAMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL13469349 | 0.73 | GRM4 (0.50) | GRM4PKMPSIP1SMN1; SMN2PARL | |
| SCHEMBL561256 | 0.70 | — | — | |
| SCHEMBL21877265 | 0.70 | MELK (0.40) | GAAPSIP1 | |
| SCHEMBL2356296 | 0.69 | ALDH1A1 (0.33) | SMN1; SMN2ALDH1A1 | |
| SCHEMBL15614518 | 0.68 | TSHR (0.41) | GRM4KMT2ASMN1; SMN2PARLPIK3CD | |
| SCHEMBL7490632 | 0.68 | KMT2A (0.44) | TDP1PKMMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL7491164 | 0.67 | PARL (0.42) | GRM4TDP1MEN1KMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0783499-B1 | BENZOFURAN DERIVATIVES AS TACHYKININ ANTAGONISTS | GLAXO GROUP LTD (GB) | 2002-10-23 | — | — | EP | disclosed |
| US-5935972-A | Benzofuran derivatives as tachykinin antagonists | GLAXO GROUP LIMITED (GB) | 1999-08-10 | — | — | US | disclosed |
| EP-0783499-A1 | BENZOFURAN DERIVATIVES AS TACHYKININ ANTAGONISTS | GLAXO GROUP LIMITED (GB) | 1997-07-16 | — | — | EP | disclosed |
| WO-1995006645-A1 | BENZOFURAN DERIVATIVES AS TACHYKININ ANTAGONISTS | GLAXO GROUP LIMITED (GB) | 1995-03-09 | — | — | WO | disclosed |