Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | KDM6B | O15054 | 1/20 | 0.43 |
| ▸ | KDM5C | P41229 | 1/20 | 0.43 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.43 |
| ▸ | PHF8 | Q9UPP1 | 1/20 | 0.43 |
| ▸ | KDM2A | Q9Y2K7 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.41 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.41 |
| ▸ | HTR2C | P28335 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 3/20 | 0.38 |
| ▸ | CHRM5 | P08912 | 2/20 | 0.38 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.38 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.38 |
| ▸ | PGR | P06401 | 1/20 | 0.38 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.38 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.38 |
| ▸ | HTR1A | P08908 | 1/20 | 0.38 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8866050 | 0.88 | TSHR (0.44) | ALDH1A1KDM4EKDM6BKDM5CEGLN1 | |
| SCHEMBL4940227 | 0.83 | ALDH1A1 (0.56) | ALDH1A1LMNAAPOBEC3AAPOBEC3GTSHR | |
| SCHEMBL5182293 | 0.83 | ALDH1A1 (0.56) | ALDH1A1LMNAAPOBEC3AAPOBEC3GTSHR | |
| SCHEMBL5165893 | 0.83 | ALDH1A1 (0.56) | ALDH1A1LMNAAPOBEC3AAPOBEC3GTSHR | |
| SCHEMBL5468558 | 0.83 | ALDH1A1 (0.56) | ALDH1A1LMNAAPOBEC3AAPOBEC3GTSHR | |
| SCHEMBL10958948 | 0.82 | KDM4E (0.59) | ALDH1A1KDM4EKDM6BKDM5CEGLN1 | |
| SCHEMBL11247778 | 0.82 | KDM4E (0.59) | ALDH1A1KDM4EKDM6BKDM5CEGLN1 | |
| SCHEMBL28076401 | 0.82 | ALDH1A1 (0.56) | ALDH1A1LMNAAPOBEC3AAPOBEC3GHTR2C | |
| SCHEMBL6128478 | 0.81 | ALDH1A1 (0.58) | ALDH1A1LMNAAPOBEC3AAPOBEC3GTSHR | |
| SCHEMBL9863320 | 0.80 | FAAH (0.49) | ALDH1A1LMNAAPOBEC3AAPOBEC3GHTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1218373-A2 | 2-PYRAZOLIN-5-ONES AS TYROSINE KINASE INHIBITORS | BASF AKTIENGESELLSCHAFT (DE) | 2002-07-03 | — | — | EP | disclosed |
| WO-2001009121-A2 | 2-PYRAZOLIN-5-ONES_AS TYROSINE KINASE INHIBITORS | BASF AKTIENGESELLSCHAFT (DE) | 2001-02-08 | — | — | WO | disclosed |