Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | KDM6B | O15054 | 1/20 | 0.43 |
| ▸ | KDM5C | P41229 | 1/20 | 0.43 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.43 |
| ▸ | PHF8 | Q9UPP1 | 1/20 | 0.43 |
| ▸ | KDM2A | Q9Y2K7 | 1/20 | 0.43 |
| ▸ | HTR2C | P28335 | 1/20 | 0.40 |
| ▸ | HAO1 | Q9UJM8 | 1/20 | 0.37 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.37 |
| ▸ | FAAH | O00519 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | ACHE | P22303 | 6/20 | 0.36 |
| ▸ | NAAA | Q02083 | 1/20 | 0.35 |
| ▸ | DGKA | P23743 | 1/20 | 0.35 |
| ▸ | FNTA | P49354 | 1/20 | 0.35 |
| ▸ | FNTB | P49356 | 1/20 | 0.35 |
| ▸ | PAOX | Q6QHF9 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7490648 | 0.88 | ALDH1A1 (0.48) | TSHRKDM4EKDM6BKDM5CEGLN1 | |
| SCHEMBL15450833 | 0.87 | TSHR (0.58) | TSHRKDM4EKDM6BKDM5CEGLN1 | |
| SCHEMBL28834687 | 0.83 | PAOX (0.50) | TSHREPHX1ALDH1A1ACHENAAA | |
| SCHEMBL28884527 | 0.83 | PAOX (0.50) | TSHREPHX1ALDH1A1ACHENAAA | |
| SCHEMBL11247778 | 0.82 | KDM4E (0.59) | TSHRKDM4EKDM6BKDM5CEGLN1 | |
| SCHEMBL10958948 | 0.82 | KDM4E (0.59) | TSHRKDM4EKDM6BKDM5CEGLN1 | |
| SCHEMBL4135037 | 0.81 | TSHR (0.55) | TSHRKDM4EKDM6BKDM5CEGLN1 | |
| SCHEMBL8846311 | 0.80 | KDM4E (0.62) | TSHRKDM4EKDM6BKDM5CEGLN1 | |
| SCHEMBL9201786 | 0.79 | ALDH1A1 (0.54) | TSHRKDM4EKDM6BKDM5CEGLN1 | |
| SCHEMBL28762968 | 0.78 | KDM4E (0.38) | KDM4EKDM6BKDM5CEGLN1PHF8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5693630-A | FOR TREATMENT OF PSYCHIATRIC DISORDERS | ASTRA AKTIEBOLAG (SE) | 1997-12-02 | — | — | US | claimed |
| US-5693630-A | FOR TREATMENT OF PSYCHIATRIC DISORDERS | ASTRA AKTIEBOLAG (SE) | 1997-12-02 | — | — | US | disclosed |
| EP-0672032-A1 | NOVEL PHENYLETHYL AND PHENYLPROPYLAMINES | Astra Aktiebolag (SE) | 1995-09-20 | — | — | EP | disclosed |