Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHR1 | P34998 | 20/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL72741 | 0.76 | CRHR1 (0.75) | CRHR1 | |
| SCHEMBL7489206 | 0.75 | CRHR1 (0.62) | CRHR1 | |
| SCHEMBL7590432 | 0.73 | CRHR1 (0.65) | CRHR1 | |
| SCHEMBL7486474 | 0.72 | CRHR1 (0.77) | CRHR1 | |
| SCHEMBL61586 | 0.72 | CRHR1 (0.79) | CRHR1 | |
| SCHEMBL7494014 | 0.72 | CRHR1 (1.00) | CRHR1 | |
| SCHEMBL62708 | 0.70 | CRHR1 (0.75) | CRHR1 | |
| SCHEMBL62629 | 0.70 | CRHR1 (0.75) | CRHR1 | |
| SCHEMBL5356924 | 0.68 | CRHR1 (1.00) | CRHR1 | |
| SCHEMBL9432085 | 0.68 | CYP1A2 (0.53) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1233949-A2 | 5-SUBSTITUTED ARYLPYRIMIDINES | NEUROGEN CORPORATION (US) | 2002-08-28 | — | — | EP | disclosed |
| US-20020072521-A1 | 5-substituted arylpyrimidines | NEUROGEN CORPORATION | 2002-06-13 | — | — | US | disclosed |
| WO-2001068614-A2 | 5-SUBSTITUTED ARYLPYRIMIDINES | NEUROGEN CORPORATION (US) | 2001-09-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020072521-A1 | 5-substituted arylpyrimidines | HTR5A, CRHR1, HTR4 | CRHR1 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.