SCHEMBL7492811

SCHEMBL7492811

COc1ccc(-c2cc(N)n3nc(-c4ccc(C)o4)nc3c2)cc1OC

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ADORA2A P29274 8/20 0.52
CSNK1D P48730 1/20 0.42
PDE4A P27815 1/20 0.41
SMN1; SMN2 Q16637 3/20 0.41
KDM4E B2RXH2 2/20 0.41
NPC1 O15118 2/20 0.41
ALDH1A1 P00352 2/20 0.41
RAB9A P51151 2/20 0.41
HSD17B10 Q99714 1/20 0.41
PKM P14618 1/20 0.40
HPGD P15428 1/20 0.40
CDK5 Q00535 1/20 0.40
CDK5R1 Q15078 1/20 0.40
BRD4 O60885 1/20 0.40
ADORA3 P0DMS8 1/20 0.39
TSHR P16473 1/20 0.38
PPARG P37231 1/20 0.38
NCOA2 Q15596 1/20 0.38
NCOA1 Q15788 1/20 0.38
NCOA3 Q9Y6Q9 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7709161 0.87 ADORA2A (0.53) ADORA2ASMN1; SMN2KDM4ENPC1ALDH1A1
SCHEMBL7711750 0.84 ADORA2A (0.57) ADORA2ASMN1; SMN2KDM4ENPC1ALDH1A1
SCHEMBL7487041 0.84 ADORA2A (0.51) ADORA2ASMN1; SMN2KDM4ENPC1ALDH1A1
SCHEMBL7708420 0.84 ADORA2A (0.51) ADORA2AKDM4EALDH1A1ADORA3
SCHEMBL7478262 0.83 ADORA2A (0.56) ADORA2ASMN1; SMN2
SCHEMBL7709121 0.83 CSNK1D (0.42) ADORA2ACSNK1DSMN1; SMN2KDM4ENPC1
SCHEMBL7708869 0.82 ADORA2A (0.49) ADORA2ASMN1; SMN2KDM4ENPC1ALDH1A1
SCHEMBL7491175 0.82 ADORA2A (0.55) ADORA2AKDM4ENPC1ALDH1A1RAB9A
SCHEMBL7711685 0.82 ADORA2A (0.57) ADORA2ASMN1; SMN2KDM4ENPC1ALDH1A1
SCHEMBL7709133 0.81 ADORA2A (0.54) ADORA2ASMN1; SMN2KDM4ENPC1ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6355653-B1 DRUG AND CARRIER FOR ANTIALLERGENS, BRAIN DISORDERS AND NEUROTRANSMITTERS HOFFMANN-LA ROCHE INC. 2002-03-12 US claimed
EP-1214322-A2 AMINO-TRIAZOLOPYRIDINE DERIVATIVES F. HOFFMANN-LA ROCHE AG (CH) 2002-06-19 EP disclosed
US-6355653-B1 DRUG AND CARRIER FOR ANTIALLERGENS, BRAIN DISORDERS AND NEUROTRANSMITTERS HOFFMANN-LA ROCHE INC. 2002-03-12 US disclosed
WO-2001017999-A2 AMINO-TRIAZOLOPYRIDINE DERIVATIVES F. HOFFMANN-LA ROCHE AG (CH) 2001-03-15 WO disclosed