Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSNK1D | P48730 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | RELA | Q04206 | 1/20 | 0.39 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | PPARG | P37231 | 1/20 | 0.38 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.38 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.38 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 3/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.38 |
| ▸ | TUBB | P07437 | 1/20 | 0.38 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7708891 | 0.87 | KDM4E (0.49) | SMN1; SMN2MEN1TP53KMT2ANPC1 | |
| SCHEMBL7708864 | 0.84 | TDO2 (0.41) | SMN1; SMN2MEN1TP53NFKB1NFKB2 | |
| SCHEMBL7709236 | 0.83 | ALDH1A1 (0.48) | SMN1; SMN2MEN1TP53NFKB1NFKB2 | |
| SCHEMBL7492811 | 0.83 | ADORA2A (0.52) | CSNK1DSMN1; SMN2TSHRPPARGNCOA2 | |
| SCHEMBL7478262 | 0.83 | ADORA2A (0.56) | SMN1; SMN2MEN1TP53NFKB1MAPK1 | |
| SCHEMBL7709024 | 0.82 | NPC1 (0.41) | SMN1; SMN2MEN1TP53NFKB1NFKB2 | |
| SCHEMBL7711697 | 0.82 | ADORA2A (0.35) | SMN1; SMN2MEN1TP53KMT2ANPC1 | |
| SCHEMBL7708813 | 0.81 | NPC1 (0.37) | MEN1TP53KMT2ANPC1MAPT | |
| SCHEMBL7708391 | 0.80 | ADORA2A (0.45) | SMN1; SMN2MEN1NFKB1NFKB2KMT2A | |
| SCHEMBL7708828 | 0.80 | RAB9A (0.51) | SMN1; SMN2MEN1TP53NFKB1NFKB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6355653-B1 | DRUG AND CARRIER FOR ANTIALLERGENS, BRAIN DISORDERS AND NEUROTRANSMITTERS | HOFFMANN-LA ROCHE INC. | 2002-03-12 | — | — | US | disclosed |