Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC3 | O15379 | 4/20 | 0.53 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.53 |
| ▸ | HDAC2 | Q92769 | 4/20 | 0.53 |
| ▸ | HDAC8 | Q9BY41 | 4/20 | 0.53 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | DHODH | Q02127 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7493234 | 1.00 | HDAC3 (0.53) | HDAC3HDAC1HDAC2HDAC8MAPK10 | |
| SCHEMBL7493821 | 0.84 | HDAC3 (0.61) | HDAC3HDAC1HDAC2HDAC8MAPK10 | |
| SCHEMBL7493816 | 0.84 | HDAC3 (0.61) | HDAC3HDAC1HDAC2HDAC8MAPK10 | |
| SCHEMBL7496099 | 0.81 | ALDH1A1 (0.56) | HDAC3HDAC1HDAC2HDAC8MAPK10 | |
| SCHEMBL7496095 | 0.81 | ALDH1A1 (0.56) | HDAC3HDAC1HDAC2HDAC8MAPK10 | |
| SCHEMBL11801755 | 0.77 | MAPT (0.49) | HDAC3HDAC1HDAC2HDAC8MAPK10 | |
| SCHEMBL7488992 | 0.77 | MAPT (0.49) | HDAC3HDAC1HDAC2HDAC8MAPK10 | |
| SCHEMBL7493927 | 0.75 | MCL1 (0.32) | HDAC3HDAC1HDAC2HDAC8MAPK10 | |
| SCHEMBL7493932 | 0.75 | MCL1 (0.32) | HDAC3HDAC1HDAC2HDAC8MAPK10 | |
| SCHEMBL4118521 | 0.74 | HDAC8 (0.41) | HDAC3HDAC1HDAC2HDAC8TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0760362-B1 | DIAMINOMETHYLIDENE DERIVATIVE | NISSHIN SEIFUN GROUP INC (JP) | 2002-08-14 | — | — | EP | disclosed |
| US-5753654-A | GASTROINTESTINAL DISORDERS | NISSHIN FLOUR MILLING CO., LTD. (JP) | 1998-05-19 | — | — | US | disclosed |
| EP-0760362-A1 | NOVEL DIAMINOMETHYLIDENE DERIVATIVE | NISSHIN FLOUR MILLING CO., LTD. (JP) | 1997-03-05 | — | — | EP | disclosed |