Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP1 | P03956 | 20/20 | 0.90 |
| ▸ | MMP13 | P45452 | 18/20 | 0.90 |
| ▸ | ADAM17 | P78536 | 15/20 | 0.90 |
| ▸ | MMP9 | P14780 | 5/20 | 0.90 |
| ▸ | MMP2 | P08253 | 5/20 | 0.90 |
| ▸ | MMP3 | P08254 | 6/20 | 0.76 |
| ▸ | ADAM10 | O14672 | 2/20 | 0.76 |
| ▸ | ADAM9 | Q13443 | 2/20 | 0.76 |
| ▸ | MMP7 | P09237 | 3/20 | 0.74 |
| ▸ | MMP8 | P22894 | 2/20 | 0.73 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3942486 | 0.94 | ADAM17 (1.00) | MMP1MMP13ADAM17MMP9MMP2 | |
| SCHEMBL2358255 | 0.94 | ADAM17 (1.00) | MMP1MMP13ADAM17MMP9MMP2 | |
| Propionamide SCHEMBL7428300 | 0.90 | ADAM17 (0.90) | MMP1MMP13ADAM17MMP9MMP2 | |
| SCHEMBL3947099 | 0.89 | MMP1 (0.82) | MMP1MMP13ADAM17MMP9MMP2 | |
| SCHEMBL12272905 | 0.87 | ADAM17 (0.86) | MMP1MMP13ADAM17MMP9MMP2 | |
| SCHEMBL8051411 | 0.87 | MMP1 (0.86) | MMP1MMP13ADAM17MMP9MMP2 | |
| SCHEMBL7325140 | 0.86 | MMP1 (0.86) | MMP1MMP13ADAM17MMP9MMP2 | |
| Apratastat SCHEMBL3946334 | 0.86 | MMP1 (1.00) | MMP1MMP13ADAM17MMP9MMP2 | |
| SCHEMBL3941871 | 0.86 | MMP1 (0.86) | MMP1MMP13ADAM17MMP9MMP2 | |
| SCHEMBL7325752 | 0.86 | MMP1 (0.86) | MMP1MMP13ADAM17MMP9MMP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6225311-B1 | Acetylenic α-amino acid-based sulfonamide hydroxamic acid tace inhibitors | AMERICAN CYANAMID COMPANY | 2001-05-01 | — | — | US | disclosed |