Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.38 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7362764 | 0.76 | MAPT (0.53) | MAPTHSP90AA1HTTSMN1; SMN2L3MBTL1 | |
| SCHEMBL7362760 | 0.76 | MAPT (0.53) | MAPTHSP90AA1HTTSMN1; SMN2L3MBTL1 | |
| SCHEMBL8646296 | 0.74 | RAB9A (0.42) | MAPTHSP90AA1HTTSMN1; SMN2SMYD3 | |
| SCHEMBL5893116 | 0.71 | RAB9A (0.44) | MAPTHTTSMN1; SMN2TDP1L3MBTL1 | |
| SCHEMBL3050407 | 0.71 | MRGPRX4 (0.43) | SMN1; SMN2POLBALDH1A1NPC1RAB9A | |
| SCHEMBL3050406 | 0.71 | MRGPRX4 (0.43) | SMN1; SMN2POLBALDH1A1NPC1RAB9A | |
| SCHEMBL4390326 | 0.69 | POLB (0.47) | TDP1POLBALDH1A1NPC1RAB9A | |
| SCHEMBL13686645 | 0.68 | MAPT (0.49) | MAPTHSP90AA1HTTSMN1; SMN2PTGER1 | |
| SCHEMBL8507600 | 0.68 | RAB9A (0.68) | MAPTSMN1; SMN2SMYD3NPC1RAB9A | |
| SCHEMBL4667925 | 0.67 | RAB9A (0.62) | MAPTSMN1; SMN2L3MBTL1PTGER1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1997011960-A1 | ANTAGONISTS OF ENDOTHELIN RECEPTORS | JAPAT LTD. (CH) | 1997-04-03 | — | — | WO | disclosed |