Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.44 |
| ▸ | PKM | P14618 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | SORD | Q00796 | 1/20 | 0.38 |
| ▸ | DRD2 | P14416 | 1/20 | 0.37 |
| ▸ | DRD4 | P21917 | 1/20 | 0.37 |
| ▸ | DRD3 | P35462 | 1/20 | 0.37 |
| ▸ | OPRK1 | P41145 | 7/20 | 0.37 |
| ▸ | DPP4 | P27487 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14481065 | 0.82 | KDM4E (0.40) | KDM4EPKMALDH1A1SORDDRD2 | |
| SCHEMBL845135 | 0.78 | OPRK1 (0.38) | KDM4EALDH1A1OPRK1LMNA | |
| SCHEMBL2115242 | 0.72 | KDM4E (0.35) | KDM4EPKMALDH1A1SORDOPRK1 | |
| SCHEMBL2115241 | 0.72 | KDM4E (0.35) | KDM4EPKMALDH1A1SORDOPRK1 | |
| SCHEMBL14481137 | 0.71 | PIK3CD (0.38) | KDM4EPKMALDH1A1OPRK1LMNA | |
| SCHEMBL14481136 | 0.71 | PIK3CD (0.38) | KDM4EPKMALDH1A1OPRK1LMNA | |
| SCHEMBL2116019 | 0.70 | PIK3CD (0.46) | ALDH1A1OPRK1DPP4 | |
| SCHEMBL14481040 | 0.68 | ALDH1A1 (0.45) | KDM4EALDH1A1OPRK1DPP4POLB | |
| SCHEMBL8783 | 0.68 | ALDH1A1 (0.45) | KDM4EALDH1A1OPRK1DPP4POLB | |
| SCHEMBL3137995 | 0.63 | HRH3 (0.52) | KDM4ESORDDRD2DRD4DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2499129-A1 | QUINOLINE AND QUINOXALINE DERIVATIVES AS KINASE INHIBITORS | UCB Pharma, S.A. (BE) | 2012-09-19 | — | — | EP | disclosed |
| WO-2011058108-A1 | QUINOLINE AND QUINOXALINE DERIVATIVES AS KINASE INHIBITORS | UCB PHARMA S.A. (BE) | 2011-05-19 | — | — | WO | disclosed |