Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSS | P25774 | 8/20 | 0.63 |
| ▸ | CTSK | P43235 | 6/20 | 0.63 |
| ▸ | CTSL | P07711 | 2/20 | 0.63 |
| ▸ | CTSB | P07858 | 2/20 | 0.63 |
| ▸ | AKT1 | P31749 | 1/20 | 0.55 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.55 |
| ▸ | ACE | P12821 | 1/20 | 0.55 |
| ▸ | REN | P00797 | 1/20 | 0.53 |
| ▸ | PTPN1 | P18031 | 3/20 | 0.51 |
| ▸ | PTPRA | P18433 | 1/20 | 0.51 |
| ▸ | ATM | Q13315 | 1/20 | 0.50 |
| ▸ | BCL2 | P10415 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13954127 | 0.92 | CTSS (0.61) | CTSSCTSKCTSLCTSBAKT1 | |
| SCHEMBL27808579 | 0.91 | CTSS (0.60) | CTSSCTSKCTSLCTSBAKT1 | |
| SCHEMBL8665277 | 0.89 | CTSS (0.58) | CTSSCTSKCTSLCTSBAKT1 | |
| SCHEMBL13954048 | 0.88 | CTSS (0.67) | CTSSCTSKCTSLCTSBHDAC8 | |
| SCHEMBL15598266 | 0.88 | CTSK (0.51) | CTSSCTSKCTSLCTSBHDAC8 | |
| SCHEMBL28103795 | 0.88 | CTSK (0.51) | CTSSCTSKCTSLCTSBHDAC8 | |
| SCHEMBL7505664 | 0.88 | CTSS (0.57) | CTSSCTSKCTSLCTSBAKT1 | |
| SCHEMBL8345787 | 0.87 | CTSS (0.64) | CTSSCTSKCTSLCTSBAKT1 | |
| SCHEMBL19359503 | 0.86 | KLK7 (0.56) | CTSSCTSKCTSLCTSB | |
| SCHEMBL19359501 | 0.86 | KLK7 (0.56) | CTSSCTSKCTSLCTSB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0364493-A1 | RENIN INHIBITING PEPTIDES WITH NONPEPTIDE LINKAGES | THE UPJOHN COMPANY (US) | 1990-04-25 | — | — | EP | claimed |
| WO-1989001488-A1 | RENIN INHIBITING PEPTIDES WITH NONPEPTIDE LINKAGES | THE UPJOHN COMPANY (US) | 1989-02-23 | — | — | WO | claimed |
| EP-0364493-A1 | RENIN INHIBITING PEPTIDES WITH NONPEPTIDE LINKAGES | THE UPJOHN COMPANY (US) | 1990-04-25 | — | — | EP | disclosed |
| WO-1989001488-A1 | RENIN INHIBITING PEPTIDES WITH NONPEPTIDE LINKAGES | THE UPJOHN COMPANY (US) | 1989-02-23 | — | — | WO | disclosed |