Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSS | P25774 | 8/20 | 0.64 |
| ▸ | CTSK | P43235 | 7/20 | 0.64 |
| ▸ | CTSB | P07858 | 3/20 | 0.64 |
| ▸ | CTSL | P07711 | 2/20 | 0.64 |
| ▸ | AKT1 | P31749 | 1/20 | 0.56 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.56 |
| ▸ | ACE | P12821 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | REN | P00797 | 1/20 | 0.52 |
| ▸ | ATM | Q13315 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30172735 | 0.92 | CTSS (0.61) | CTSSCTSKCTSBCTSLAKT1 | |
| SCHEMBL7494181 | 0.87 | CTSS (0.63) | CTSSCTSKCTSBCTSLAKT1 | |
| SCHEMBL30172741 | 0.86 | CTSS (0.61) | CTSSCTSKCTSBCTSLAKT1 | |
| SCHEMBL16999847 | 0.86 | CTSS (0.61) | CTSSCTSKCTSBCTSLAKT1 | |
| SCHEMBL27808579 | 0.85 | CTSS (0.60) | CTSSCTSKCTSBCTSLAKT1 | |
| SCHEMBL9610766 | 0.85 | HDAC8 (0.72) | CTSSCTSKCTSBCTSLAKT1 | |
| SCHEMBL3944495 | 0.85 | HDAC8 (0.72) | CTSSCTSKCTSBCTSLAKT1 | |
| SCHEMBL28591251 | 0.85 | CTSL (0.61) | CTSSCTSKCTSBCTSLAKT1 | |
| SCHEMBL7505664 | 0.85 | CTSS (0.57) | CTSSCTSKCTSBCTSLAKT1 | |
| SCHEMBL27515453 | 0.84 | CTSS (0.59) | CTSSCTSKCTSBCTSLAKT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004022534-A1 | ARYLGLYCINE DERIVATIVES FOR USE AS GLYCINE TRANSPORT INHIBITORS | NPS ALLELIX CORP. (CA) | 2004-03-18 | — | — | WO | disclosed |