Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | GNAI3 | P08754 | 7/20 | 0.41 |
| ▸ | GNAO1 | P09471 | 7/20 | 0.41 |
| ▸ | GNAI1 | P63096 | 7/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.37 |
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.37 |
| ▸ | GMNN | O75496 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | THPO | P40225 | 1/20 | 0.37 |
| ▸ | MTOR | P42345 | 1/20 | 0.37 |
| ▸ | BLM | P54132 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | CETP | P11597 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | UBE2N | P61088 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6495574 | 1.00 | LMNA (0.42) | LMNAGNAI3GNAO1GNAI1SIGMAR1 | |
| SCHEMBL18612783 | 0.89 | GNAO1 (0.46) | LMNAGNAI3GNAO1GNAI1SIGMAR1 | |
| SCHEMBL21581261 | 0.89 | GNAO1 (0.46) | LMNAGNAI3GNAO1GNAI1SIGMAR1 | |
| SCHEMBL21581280 | 0.89 | GNAO1 (0.46) | LMNAGNAI3GNAO1GNAI1SIGMAR1 | |
| SCHEMBL28210517 | 0.89 | GNAO1 (0.46) | LMNAGNAI3GNAO1GNAI1SIGMAR1 | |
| SCHEMBL18761564 | 0.89 | GNAO1 (0.46) | LMNAGNAI3GNAO1GNAI1SIGMAR1 | |
| SCHEMBL22019451 | 0.89 | GNAO1 (0.46) | LMNAGNAI3GNAO1GNAI1SIGMAR1 | |
| SCHEMBL369682 | 0.87 | GNAO1 (0.43) | GNAI3GNAO1GNAI1SIGMAR1FDPS | |
| SCHEMBL28180033 | 0.86 | GNAO1 (0.43) | GNAI3GNAO1GNAI1SIGMAR1FDPS | |
| SCHEMBL14976680 | 0.85 | SIGMAR1 (0.37) | GNAI3GNAO1GNAI1SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1187828-A1 | QUINOLINE DERIVATIVES AS ANTIBACTERIALS | SMITHKLINE BEECHAM PLC (GB) | 2002-03-20 | — | — | EP | disclosed |
| WO-2000078748-A1 | QUINOLINE DERIVATIVES AS ANTIBACTERIALS | SMITHKLINE BEECHAM P.L.C. (GB) | 2000-12-28 | — | — | WO | disclosed |