SCHEMBL7494776

SCHEMBL7494776

Cc1c(N2CC[C@H](n3cccc3)C2)c(F)cn2c(=O)c(OC(=O)O)cc(C3CC3)c12

nearest known ligand 0.36

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
KCNH2 Q12809 8/20 0.36
SCN5A Q14524 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7496930 0.95 KCNH2 (0.34) KCNH2SCN5A
SCHEMBL7503333 0.87 SCN5A (0.43) KCNH2SCN5A
SCHEMBL7503330 0.87 SCN5A (0.43) KCNH2SCN5A
SCHEMBL7503826 0.87 KCNH2 (0.37) KCNH2SCN5A
SCHEMBL7502507 0.86 KCNH2 (0.34) KCNH2SCN5A
SCHEMBL7504904 0.86 ALDH1A1 (0.40) KCNH2SCN5A
SCHEMBL7546411 0.86 ALDH1A1 (0.40) KCNH2SCN5A
SCHEMBL7502899 0.86 ALDH1A1 (0.40) KCNH2SCN5A
SCHEMBL7499874 0.84 TOP1 (0.39) KCNH2SCN5A
SCHEMBL7497603 0.84 KCNH2 (0.35) KCNH2SCN5A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0723545-B1 QUINOLIZINONE TYPE COMPOUNDS ABBOTT LAB (US) 2002-05-08 EP claimed