Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRA | P25101 | 4/20 | 0.39 |
| ▸ | EDNRB | P24530 | 3/20 | 0.37 |
| ▸ | P2RX7 | Q99572 | 4/20 | 0.35 |
| ▸ | BRS3 | P32247 | 3/20 | 0.35 |
| ▸ | HTR2A | P28223 | 2/20 | 0.35 |
| ▸ | HTR2C | P28335 | 2/20 | 0.35 |
| ▸ | HTR2B | P41595 | 2/20 | 0.35 |
| ▸ | PGK1 | P00558 | 1/20 | 0.34 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8785836 | 0.82 | EDNRA (0.40) | EDNRAEDNRBP2RX7ALDH1A1CYP3A4 | |
| SCHEMBL8589478 | 0.80 | EDNRA (0.45) | EDNRASLC22A12LMNASMN1; SMN2ALDH1A1 | |
| SCHEMBL7498870 | 0.78 | EDNRA (0.59) | EDNRAEDNRBSMN1; SMN2ALDH1A1 | |
| SCHEMBL7507367 | 0.76 | EDNRA (0.48) | EDNRAEDNRBLMNASMN1; SMN2ALDH1A1 | |
| SCHEMBL8434241 | 0.74 | EDNRA (0.53) | EDNRAEDNRBLMNASMN1; SMN2ALDH1A1 | |
| SCHEMBL8785947 | 0.72 | P2RX7 (0.39) | P2RX7BRS3SLC22A12SMN1; SMN2ALDH1A1 | |
| SCHEMBL8784871 | 0.72 | EDNRA (0.48) | EDNRASLC22A12LMNASMN1; SMN2ALDH1A1 | |
| SCHEMBL7498869 | 0.71 | EDNRA (0.39) | EDNRAEDNRBP2RX7BRS3SLC22A12 | |
| SCHEMBL8784106 | 0.70 | EDNRA (0.47) | EDNRASLC22A12SMN1; SMN2ALDH1A1CYP3A4 | |
| SCHEMBL8592901 | 0.70 | EDNRA (0.70) | EDNRASLC22A12SMN1; SMN2ALDH1A1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0776325-B1 | NOVEL USE AND NOVEL DERIVATIVES OF IMIDAZOLE, METHOD FOR PREPARING SAME, NOVEL INTERMEDIATES THUS OBTAINED, MEDICINAL APPLICATIONS OF SAME AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME | AVENTIS PHARMA SA (FR) | 2002-11-20 | — | — | EP | claimed |
| EP-0776325-A1 | NOVEL USE AND NOVEL DERIVATIVES OF IMIDAZOLE, METHOD FOR PREPARING SAME, NOVEL INTERMEDIATES THUS OBTAINED, MEDICINAL APPLICATIONS OF SAME AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME | ROUSSEL UCLAF (FR) | 1997-06-04 | — | — | EP | disclosed |