Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRA | P25101 | 11/20 | 0.48 |
| ▸ | EDNRB | P24530 | 10/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 3/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7498870 | 0.89 | EDNRA (0.59) | EDNRAEDNRBKDM4EALDH1A1HPGD | |
| SCHEMBL6159408 | 0.88 | EDNRA (0.52) | EDNRAKDM4EALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL7506638 | 0.86 | EDNRA (0.45) | EDNRAEDNRBKDM4EALDH1A1HPGD | |
| SCHEMBL6580607 | 0.85 | EDNRA (0.42) | EDNRAEDNRBKDM4EALDH1A1HPGD | |
| SCHEMBL6162886 | 0.85 | EDNRA (0.49) | EDNRAEDNRBKDM4EALDH1A1HPGD | |
| SCHEMBL8434241 | 0.80 | EDNRA (0.53) | EDNRAEDNRBKDM4EALDH1A1HPGD | |
| SCHEMBL6579951 | 0.79 | SMN1; SMN2 (0.41) | EDNRAKDM4EALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL7503953 | 0.79 | EDNRA (0.53) | EDNRAKDM4EALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL8434286 | 0.78 | EDNRA (0.64) | EDNRAEDNRBKDM4EALDH1A1HPGD | |
| SCHEMBL8431316 | 0.78 | EDNRA (0.52) | EDNRAEDNRBKDM4EALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0776325-B1 | NOVEL USE AND NOVEL DERIVATIVES OF IMIDAZOLE, METHOD FOR PREPARING SAME, NOVEL INTERMEDIATES THUS OBTAINED, MEDICINAL APPLICATIONS OF SAME AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME | AVENTIS PHARMA SA (FR) | 2002-11-20 | — | — | EP | claimed |